Session Information
Date: Thursday, June 8, 2017
Session Title: Parkinson’s Disease: Clinical Trials, Pharmacology And Treatment
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: To determine wearing off frequency in different stages of Parkinson’s disease (PD).
Background: Levodopa is the gold standard in the symptomatic treatment of PD. The most frequent motor complication in patients treated with levodopa is wearing off (WO) (patient suffering from predictable “off” states due to levodopa having a short term clinical effect). Different WO rates have been reported in early stage (ranging between 0%-42%).
Methods: One hundred seventy-five patients were included in the study. Staging of PD was determined using “Hoehn-Yahr Staging” (HYS). Wearing Off Questionnaire (WOQ), consisting of 19 items, was used to evaluate wearing off.
Results: The number of patients in each HYS are given in Table 1.
[table1]
Overall, WO frequency was 67,43% (118/175 patients). Mean WOQ scores for each HYS are summarized in Table 2.
[table2]
According to WOQ, WO frequency was 81,82% (63/77 patients) in HYS 2; 77,36 (41/53 patients) in HYS 2,5; 80,95 %(4/21 patients) in HYS 3; 58,33% (7/12 patients) in HYS 4 and 25% (3/12) in HYS 5 (Figure 1).
[figure1]
Conclusions: We report a WO frequency over 50% even in early stages of the disease.
To cite this abstract in AMA style:
H. Cotur Levent, E. Bayram, M. Akbostanci. Wearing Off Frequency in Different Hoehn-Yahr Stages in Parkinson’s Disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/wearing-off-frequency-in-different-hoehn-yahr-stages-in-parkinsons-disease/. Accessed May 16, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/wearing-off-frequency-in-different-hoehn-yahr-stages-in-parkinsons-disease/