Neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio and Parkinson’s Disease: Preliminary report
Objective: We conducted a pilot study to determine the association between the neutrophil to lymphocyte ratio (NLR), he lymphocyte to monocyte ratio (LMR), the levels…Alpha-synuclein oligomer and rotenone treatments injury the dopaminergic neuron via inhibiting the expression of gene SEMA6D
Objective: To investigate the expression of Semaphorin6D (SEMA6D) and its interaction with Plexin-A1 in cellular Parkinson's disease(PD) models induced by α-synuclein and rotenone. Background: In…Measuring salivary cortisol levels in persons with Parkinson’s disease (PD)
Objective: To better characterize the relationship between salivary cortisol and psychological stress in persons with Parkinson’s disease (PD). Background: Psychological stress is known to exacerbate…Neuropsychiatric disorders in observed patients with Parkinson’s disease
Objective: Parkinson's disease (PD), - chronic progressive disease of the brain from the degeneration of the nigrostriatal neurons in the basal ganglia and impaired function.…The International Parkinson and Movement Disorder Society Non-Motor Scale (MDS-NMS) for Parkinson’s Disease: Preliminary results from an international validation
Objective: To provide an update on the ongoing international validation programme of an expanded, refined and improved scale for the assessment of non-motor symptoms (NMS)…Low-Fat Versus Ketogenic Diet In Parkinson’s Disease: A Pilot Randomized Controlled Trial
Objective: To compare the plausibility, safety, and efficacy of a low-fat, high-carbohydrate diet versus a ketogenic diet in a hospital clinic of PD patients. Background:…A Phase 2 Efficacy Study of CX-8998, a Potent and Selective T-Type Calcium (Cav3) Modulator in Parkinson’s disease Tremor (PDT) Patients: Design and Dose-Selection Rationale
Objective: The objective of this study is to access the efficacy of CX-8998 using the MDS-UPDRS Tremor Score (MDS-UPDRS-TS) and a digital biomarker platform, while…Motor and non-motor correlates of APOE-ε4 mediated cerebrospinal fluid concentrations of amino acids and monoamine metabolites in dementia with Lewy bodies compared with Alzheimer’s dementia and healthy controls
Objective: To study associations of cerebrospinal fluid (CSF) amino acids and monoamine metabolites with motor and non-motor features in dementia with Lewy bodies (DLB) compared…The possible neuroprotective potential of galantamine along with soya-lecithin and hydroxychloroquine against ICV-STZ induced cognitive dysfunction in rats
Objective: The present study investigates the possible neuroprotective potential of galantamine with soya-lecithin and HCQ against intracerebroventricular streptozotocin (ICV-STZ) induced memory impairment in a rat…Interaction between mGluR5 and NR2B is increased in 6-OHDA parkinsonian rats with L-dopa-induced dyskinesiaInteraction between mGluR5 and NR2B is increased in 6-OHDA parkinsonian rats with L-dopa-induced dyskinesia
Objective: In this study, we verified whether the interaction of mGluR5 and NR2B exerts an important effect on the development of LID. Background: L-dopa is…
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