A founder French-Canadian GBA mutation, p.W378G, as a cause for synucleinopathies and Gaucher disease
Objective: To examine and characterize founder GBA mutations in the French-Canadian (FC) population Background: GBA mutations are the most common genetic risk factors for Parkinson’s…Does dopaminergic denervation of specific anatomical regions of the basal ganglia correlate with clinical features of Parkinsonism: A quantitative DaTscan study
Objective: To correlate different clinical features of parkinsonism with regional variations of presynaptic dopaminergic dysfunction of the basal ganglia using quantitative DaTscans. Background: DaT-SPECT imaging…Clinical and functional network features of visuoperceptual disturbances in Parkinson’s disease
Objective: To clarify the relationship between functional connectivity changes in the brain and visuoperceptual disturbances in patients with Parkinson's disease (PD). Background: Patients with PD…Contribution of individual motor signs to striatal dopamine deficiency in parkinsonism
Objective: The primary aim of the study was to investigate if any individual motor sign could be used clinically to predict striatal dopamine deficiency. Secondary…A comprehensive digital biomarker active testing and passive monitoring suite for the remote and frequent assessment of motor symptom progression in Parkinson’s disease
Objective: We present the development and design of a comprehensive digital biomarker smartphone application (app) for remote and frequent assessments of motor symptom severity and…Altered putamen and cerebellum connectivity between different subtypes of Parkinson’s disease
Objective: we investigate the functional connectivity (FC) patterns of the putamen between different subtypes of PD) and healthy controls, and explore its clinical significance. Background:…Discriminating Idiopathic PD Patients and Controls in PPMI Using Integrative Multi-Modal Neuroimaging Analysis with Graph Convolutions
Objective: To discriminate Parkinson’s disease (PD) patients and controls in the Parkinson’s Progression Markers Initiative (PPMI) cohort according to MRI features using a novel a…What happens when I watch a ballet? Preliminary fMRI findings on somatosensory empathy in Parkinson Disease
Objective: To investigate the neural components of the mirror sensor-motor system recruited by a dance movement in a motor disorder, such as PD is. Background:…Executive Function and Frontoparietal Network Association in Freezing of Gait
Objective: To investigate the relationship between executive function and frontoparietal network (FPN) functional connectivity in Parkinson’s disease patients with freezing of gait (PD-FOG). Background: FPN…Anti-glutamatergic effect of safinamide in Parkinson’s Disease: A TMS study
Objective: To test the effect of safinamide, at the doses of 50 and 100 mg/day, on primary motor cortex (M1) excitability and glutamatergic neurotransmission in…
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