Is Heart Rate variability a differential biomarker in REM sleep behavior disorder, Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy?
Objective: Heart rate deceleration capacity (DC) and heart rate variability index (HRVI) as potential biomarkers for autonomic dysregulation were studied in subjects (each group N=10)…Olfactory Hallucinations as a Non-motor sign of Parkinson’s disease – A cross-sectional study amongst patients in a tertiary movement center
Objective: Assess the prevalence of olfactory hallucinations (OlfH) in patients presenting to a tertiary movement disorders outpatient clinic. Background: Hallucinations can be considered a non-motor…Evaluation of Non-motor Symptoms of Parkinson’s Disease Patients in a Hong Kong Chinese population using the HK-NMSQuest
Objective: This study aimed to evaluate the non-motor symptom profiles of Hong Kong Chinese Parkinson’s Disease patients using the newly validated HK-NMSQuest, which is based…Objective intestinal dysfunction in REM sleep behaviour disorder
Objective: To study objectively measured intestinal function, defined by intestinal volume, transit times, and colonic motility patterns in patients with idiopathic REM sleep behaviour disorder…Influence of dopamine deficiency on interhemispheric crosstalk in Parkinson’s disease
Objective: To identify the significance of dopaminergic depletion in Parkinson’s disease (PD) on interhemispheric crosstalk using a complex bimanual tapping task. Background: Dopamine deficiency in…Distinct Blood Leukocytes Expression Profiles of Long Non-coding RNAs and mRNAs in Parkinson’s disease patients
Objective: The study aims to identify the significant altered long non-coding RNAs (LncRNA) mRNAs expression profiles of blood leukocytes from Parkinson's disease (PD) patients, which…Identification of putative serum biomarkers for parkin-related Parkinson’s disease by metabolome analysis
Objective: Parkin is known as the causative gene of autosomal recessive familial Parkinson’s disease (parkin-PD). It remains unclear how parkin dysfunction associates with the dopaminergic…Bmal1 deficiency aggravates MPTP-induced dopaminergic cell death through promoting neuroinflammation
Objective: Bmal1 is one of the most important central clock genes of circadian rhythm. Circadian rhythm dysfunction is one of the non-motor symptoms in Parkinson’s…Antibodies to alpha-Synuclein in Parkinson disease
Objective: Alpha-synuclein (α-syn) plays a very important role in pathogenesis of Parkinson’s disease (PD). There are enough evidence of neuroinflammation in the brain tissue of…Peripheral Inflammatory Mediators in Parkinson’s Disease – A Potential Biomarker
Objective: i.To determine if post-translationally modified phosphorylated α-synuclein levels are altered in the peripheral blood of Parkinson’s disease (PD) patients compared to control subjects. ii.To…
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