Speech intelligibility and comprehensibility in Slovak patients with Parkinson’s disease
Objective: The aim of our study was to evaluate intelligibility and comprehensibility (intelligibility in context) and its relationship with MDS-UPDRS (sub)scores in Slovak population of…α-synuclein antibody 5G4 identifies manifest and prodromal Parkinson’s disease in colonic mucosa
Objective: The aim of this study was to evaluate colonic mucosa staining using the 5G4 antibody, specific only for the disease-associated form of α-synuclein, in…Personality Traits and Sleep Quality in Parkinson’s disease patients
Objective: To investigate which types of personality traits are related to sleep quality in Parkinson’s disease (PD) patients. Background: Sleep disturbance is a common nonmotor…Intercultural differences in the frequency of impulsive control disorders in Parkinson’s disease
Objective: To study if there were intercultural differences in the prevalence of these impulse control disorders in PD. Background: Impulse control disorders (ICD) era common…Assessing hemifacial spasm: The HFSG scale
Objective: To create and validate an objective assessing tool to diagnose and monitor HFS and the efficacy of its treatments. Background: Hemifacial spasm (HFS), is…Specific active immunotherapy (SAIT) against alpha-synuclein with AFFITOPE® PD01A and PD03A: Results from the AFF009 phase I trial
Objective: Phase I study with AFFITOPE® PD01A and PD03A to assess safety and tolerability as well as immunogenicity of this approach in MSA patients. Background:…Relationship between non-motor symptom symptoms and clinical symptoms in Parkinson’s disease using “Non-Motor Symptom assessment scale for Parkinson’s disease”
Objective: We evaluated the relationship between non-motor symptoms and clinical signs in patients with Parkinson’s disease (PD). Background: Patients with Parkinson's disease (PD) manifest not…Intraoperative local field potential recordings from deep brain stimulation electrodes help predict efficacy of subthalamic nucleus stimulation in patients with Parkinson’s disease
Objective: Subthalamic nucleus (STN) deep brain stimulation(DBS) is an effective treatment for advanced Parkinson's disease (PD). Two electrophysiological techniques aid identification of the optimal target.…Polysomnographic data in Dementia with Lewy Bodies: Correlation with clinical features and comparison with other alfa-synucleinopathies
Objective: 1) Polysomnography (PSG) assessment of sleep in Dementia with Lewy Bodies (DLB). 2) Correlation between PSG data, fluctuations and hypersomnolence. 3) Comparison of PSG…Intrastriatal Fyn silencing as a gene therapy strategy to manage levodopa induced dyskinesia in a mice model of Parkinson’s disease
Objective: To genetically abrogate Fyn expression to reduce levodopa induced dyskinesia (LID) in the 6-OHDA mice model of Parkinson’s disease (PD), using intrastriatal-injected lentiviral (LV)…
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