Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice
Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…Activation of chaperone-mediated autophagy reduces oligomeric alpha-synuclein accumulation in LRRK2(R1441G) knockin mouse model of Parkinson’s disease (PD)
Objective: To determine age-dependent accumulation of oligomeric alpha-synuclein in the brain of aged LRRK2(R1441G) knockin mice; and to explore whether activation of chaperone-mediated autophagy (CMA)…Prefrontal cortical stimulation to treat anxiety and depression in Parkinson’s disease
Objective: The aims of this study are 1) to study the neurophysiology underlying anxiety and depression in PD patients, and 2) to determine whether cortical…Direction of Turning in Parkinson’s Disease: More Affected Side or Less Affected Side?
Objective: The aim of this study is to investigate differences of gait characteristics according to direction of turning more and less affected side (MAS and…Neuropathological correlates of psychiatric disorders in PD
Objective: To test the hypothesis that neuropsychiatric symptoms (NPS) in PD are associated with histopathologically confirmed neuronal loss and gliosis (NLG) in the locus coeruleus…Parkinson’s disease anxiety is associated with Lewy bodies in the Anterior Cingulate
Objective: The goal of this study is to determine if there is an association between anxiety and the presence and regional distribution of Lewy bodies…Dissociate effect of dopaminergic therapy in reward expectation and prediction error in PD patients with comorbid impulse control disorder
Objective: To study EEG oscillatory activity associated to reward prediction error in Parkinson’s disease (PD) patients with impulse control disorders (ICD) and determine how dopaminergic…FuRST2.0: Development of a modified functional rating scale for use in premanifest and early-manifest Huntington’s disease
Objective: Develop a patient-reported outcome (PRO) modification of the Functional Rating Scale for pre-Huntington Disease (FuRST-pHD) using focus group, Delphi panel and cognitive pre-testing methodology.…The PDSAFE falls prevention programe for people with Parkinson’s: A multicentre randomised controlled trial
Objective: The aim was to examine the effectiveness of an exercise and strategy based intervention (PDSAFE) for fall reduction. Background: Evidence suggests exercise-based interventions might…STN deep brain stimulation can directly suppress levodopa-induced dyskinesia in Parkinson’s disease
Objective: The study aims to evaluate the effect of bilateral STN-DBS on levodopa-induced peak-dose dyskinesia in patients with PD. Background: Dyskinesia is among the most…
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