DIRECT DBS: A Prospective, Multicenter Clinical Study with Double-Blinding for a Directional Deep Brain Stimulation Lead – Visualization of Optimal Directionally Stimulated Anatomy
Objective: To visualize the volumes of activated tissue in relation to the neuroanatomy for the optimal stimulation parameters in Ring Mode (omnidirectional) stimulation in comparison…Quantitative assessment of the effectiveness of adaptive Deep Brain Stimulation in Parkinson’s disease
Objective: To determine the effectiveness of Adaptive Deep Brain Stimulation (aDBS) in PD patients compared to cDBS and non-medicated PD patients (OFF). Background: aDBS based…The Effect of Conduction Exercise and Self-acupressure in Treatment of Parkinson’s Disease: A Pilot Study
Objective: To evaluate the efficacy and safety of exercise regime combining Conduction exercise (CE) and self-acupressure (SA) in treating both motor symptoms (MS) and non-motor…Design of a Phase 3 Efficacy and Safety Trial of Accordion Pill™ Carbidopa/Levodopa for Parkinson’s Disease (PD) Patients Experiencing Motor Fluctuations
Objective: To review the design and unique features of an ongoing phase 3 trial of a gastric-retentive formulation of carbidopa/levodopa (CD/LD), the Accordion Pill™ (AP),…Does motor laterality affect the development of dyskinesia in patients with Parkinson’s disease?
Objective: To investigate the effects of motor laterality on the development of levodopa-induced dyskinesia (LID) in patients with de novo Parkinson’s disease (PD). Background: LID…Levodopa induced dyskinesia is preventable (15 years experience using continuous dopaminergic stimulation)
Objective: To evaluate whether levodopa induced dyskinesia is preventable in the treatment of patients with Parkinson’s disease. Background: Dyskinesia is one of the major complications…Magnetic resonance imaging-guided focused ultrasound unilateral pallidotomy for Parkinson’s disease: A report of 2 patients
Objective: To present two patients of Parkinson’s disease (PD) with Magnetic resonance imaging-guided focused ultrasound (MRgFUS) unilateral pallidotomy. Background: MRgFUS is a new technology that…Highly-selective blockade of 5-HT2A receptors with EMD-281,014 reduces the severity of L-DOPA-induced psychosis and dyskinesia in the MPTP-lesioned marmoset model of Parkinson’s disease
Objective: To investigate the effect of the highly-selective serotonin 2A (5-HT2A) receptor EMD-281,014 on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced psychosis-like behaviours (PLBs) and dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned…Ocular motor function in stiff person syndrome – Role of GABA and beyond
Objective: Delineate pathophysiology of gaze-holding function in stiff person syndrome (SPS). Background: Glutamic acid decarboxylase (GAD) catalyzes conversion of glutamate to gamma-aminobutyric acid (GABA). Anti-GAD…Peculiarities of Opsoclonus-Myoclonus Syndrome in India: A Systematic Review of reported cases
Objective: The aim of the study was to study the reported cases on opsoclonus-myoclonus syndrome in India and to analyze its peculiarities in comparison with…
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