Combined therapy VS only levodopa therapy in a 5-years follow up cohort
Objective: Describe the frequencies of appearance of motor fluctuations, impulse control disorders, in two therapeutic regimes: combined therapy (levodopa plus an other antiparkinsonian drug) or…Efficacy of opicapone compared to entacapone in catechol-O-methyltransferase inhibitor-naïve Parkinson’s disease patients recently diagnosed with motor fluctuations: A post-hoc conservative analysis
Objective: To assess the efficacy of opicapone 50 mg (OPC 50 mg), compared with entacapone (ENT), in catechol-O-methyltransferase inhibitor (COMTi)-naïve Parkinson’s disease (PD) patients recently…Calcitriol Treatment Attenuates Dopaminergic Neurodegeneration in Mice Model of Parkinson’s Disease
Objective: To investigate the role and mechanism of Calcitriol (1,25-dihydroxyvitamin D3) in Parkinson's mice and cell model Background: Parkinson's disease (PD) is a neurodegenerative disorder…Effect of opicapone and entacapone on levodopa short duration response
Objective: To evaluate the effect of opicapone (OPC) 50 mg versus entacapone (ENT) on levodopa short duration response (SDR). Background: OPC, a once-daily catechol-O-methyltransferase inhibitor,…Effectiveness and Tolerability of Mirabegron and Behavioral Therapy in Patients with Parkinson’s Disease and Overactive Bladder: A Prospective, Randomized, Placebo-Controlled Pilot Study
Objective: To assess safety, tolerability, and efficacy of mirabegron and Pelvic floor Exercise (PFE)-based behavioral therapy for the treatment of overactive bladder (OAB) in patients…Neuroprotective and neuromodulatory properties of Olea purpurea leaf extract in MPTP intoxicated Parkinsonian rat model
Objective: This study aimed to isolate and characterize Olea purpurea leaf extract, and its neuroprotective effect in MPTP induced parkinsonian rat model. Background: Parkinson's disease (PD), also…Automated classification of neurodegenerative parkinsonian syndromes using multimodal magnetic resonance imaging in a clinical setting
Objective: To evaluate the accuracy for the categorization of parkinsonian syndromes of a machine learning algorithm trained with a research cohort and tested on an…Quantitative evaluation of Multiple System Atorphy by triaxial accelerometers and 9-hole peg test
Objective: We need a concise and responsive biomarker for multiple system atrophy (MSA). Background: In Japan, the majority of patients of MSA are of the…Niemann-Pick Type C Presenting as Progressive Supranuclear Palsy
Objective: We report a very old patient who presented the clinical features of progressive supranuclear palsy (PSP) including supranuclear vertical gaze palsy with prominent cerebellar…Patient Characteristics, Treatment Patterns and Disease Burden in People with Parkinson’s Disease: Insights from the Parkinson’s Disease Real-World Impact Assessment (PRISM) Study
Objective: Data from the PRISM study on patient characteristics, treatment patterns and burden of disease in people with Parkinson’s disease (PwP) are presented. Background: PRISM…
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