Northwestern University Feinberg School of Medicine Parkinson’s disease and Movement Disorders Center Biorepository: bringing the clinic and lab together
Objective: To establish a biobank of DNA and tissue samples from a population of movement disorder patients, their family members and healthy controls recruited from…Association between SNCA and clinical phenotypes of Parkinson’s disease in southern Chinese
Objective: The aim was to investigate the association between SNCA and clinical phenotypes of Parkinson’s disease (PD) in southern Chinese. Background: SNCA gene plays an…Sensitive biomarker of Parkinson’s disease linked to mutations in the glucocerebrosidase gene
Objective: To find a biomarker for development of Parkinson’s disease (PD) in carriers of mutations in the glucocerebrosidase gene (GBA). Background: Mutations in the GBA…ADAM10 polymorphisms are not associated with susceptibility to Parkinson’s disease and Parkinson’s disease with cognitive impairment in a Chinese cohort
Objective: This study is to explore the relationship between the rs442495 and rs593742 loci of ADAM10 gene and Parkinson's disease( PD) or PD cognitive impairment.…The Fragile X Mental Retardation Protein is lost prior to the appearance of Lewy pathology in Parkinson’s disease
Objective: The degeneration of dopaminergic (DA) substantia nigra pars compacta (SNc) neurons is a pathological hallmark of Parkinson's disease (PD). Cell death in PD is…Profile of miRNA expression in CSF of Parkinson’s disease identifies miR-409-3p regulating the apoptosis of dopamine neurons
Objective: To improve the precise diagnosis of PD at early stage requires more feasible and objective methods. MicroRNA (miRNA) was believed to be a potential…Motor and cognitive symptoms in parkinsonism are associated with loss of long-range white matter fibers: Structural network changes in Vascular Parkinsonism and Parkinson’s disease
Objective: This study seeks to identify structural brain circuitry changes that may help to explain the appearance and severity of parkinsonism symptoms in clinical cohorts…Impaired Structural Connectivity in Parkinson’s Disease and its Neuropsychological Correlates
Objective: The aim of this study was to detect disrupted structural connectivity in Parkinson's disease (PD) patients classified according to their cognitive status, with and…Inertial-sensor based full-body kinematics reveals an unstable gait with increased variability in patients with evidence of dopaminergic denervation with 123I-FP-CIT SPECT
Objective: Distinguish patients with and without dopaminergic denervation (as assessed by 123I-FP-CIT-SPECT – DaTscan) with Inertial-sensor full body kinematics (FBK) assessment. Background: The differential diagnosis…Retinal Pathology in Parkinson’s Disease: A Longitudinal Study with Optical Coherence Tomography
Objective: The aim of this study was to find retinal pathology in Parkinson’s disease (PD) via Optical Coherence Tomography (OCT) that deteriorates over time, as…
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