Comprehensive Screening of Genetic, Genomic, Mitochondrial, and Microbiome Associations with Phenotypic Measures in the Dominican Republic PKAN Cohort
Objective: Establish novel molecular predictors of phenotypic variation using screening of genomic, transcriptomic, mitochondrial, microbiome, and clinical features. Background: Pantothenate Kinase Associated Neurodegeneration (PKAN), also…Interrater Agreement for Movement Disorder Classification in Children with Mixed Movement Disorders
Objective: To determine interrater agreement on the classification component of the Movement Disorders-Childhood Rating Scale (MD-CRS). Background: The MD-CRS consists of three parts: classification, general assessment, and…SNCA hypomethylation in rapid eye movement sleep behavior disorder is a potential biomarker for Parkinson’s disease
Objective: We aimed to explore whether there were different distributions of α-synuclein at a genetic and/or protein level in patients with iRBD. Background: α-Synuclein has been related to…Sexual dysfunction associated with deep brain stimulation of the Globus Pallidus pars interna
Objective: To explore sexual dysfunction (SD) in a dystonia patient with deep brain stimulation of the Globus Pallidus pars interna (GPi DBS). Background: There is…Probabilistic response mapping in a cohort of mixed dystonia patients with bilateral pallidal DBS
Objective: Assess validity and feasibility of a probabilistic response mapping for isolated and combined dystonia. Background: Probabilistic response mapping is a promising tool to estimate the expected benefit of pallidal…“Motor” DDS: is motor sensitization underestimated after STN-DBS?
Objective: Dopamine dysregulation syndrome (DDS) is a phenomenon where Parkinson’s disease (PD) patients develop an addictive pattern of dopaminergic drug intake, mainly to avoid the…Differential patterns of gray matter volume in responders and non-responders with Parkinson’s disease after deep brain stimulation
Objective: To identify the patterns of gray matter volume by voxel-based morphometry (VBM) in responders and non-responders with Parkinson’s disease (PD) after deep brain stimulation…Asleep versus Awake DBS: Real World Evidence from the Product Surveillance Registry
Objective: Deep brain stimulation (DBS) has traditionally been performed “awake” under local anesthesia using intra-operative test stimulation to confirm lead placement. Several recent studies have…Uptake in Directional Stimulation and Primary Cell Longevity in Deep Brain Stimulation of Globus Pallidus Pars Interna for Parkinson’s Disease
Objective: To retrospectively assess the use of directional programming in deep brain stimulation of globus pallidus pars interna (GPi-DBS) in patients with Parkinson’s disease (PD).…Bioengineered nigrostriatal constructs model Lewy pathology
Objective: To better understand Parkinson’s disease (PD) pathophysiology and enhance therapeutic development by bioengineering an in vitro nigrostriatal system that mimics the complex architecture of…
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