Type 2 diabetes mellitus may worsen severity of motor symptoms in people with Parkinson’s disease
Objective: We aimed to determine whether co-morbid type 2 diabetes mellitus (T2DM) would impact the motor or non-motor symptom severity in people with Parkinson’s (PwP).…The role of dementia in Parkinson’s disease
Objective: To identify cognitive and visual-spatial disorders in patients with Parkinson's disease. Background: In the clinical picture of Parkinson's disease, non-motor symptoms acquire great importance,…The interplay between asymmetric dopaminergic degeneration, brain structural changes and cognition in de-novo PD: The PPMI dataset
Objective: To characterize the impact of asymmetric dopaminergic degeneration, measured with I123-ioflupane SPECT (DATSCAN), on cortical integrity and cognitive deficits, in de-novo right-handed PD patients.…Association of gait domains with cognitive and neuropsychiatric domains in patients with Parkinson’s disease: A Brazilian exploratory study
Objective: (i) To examine the association of gait domains (single and dual task (DT) walk) with cognitive and neuropsychiatric domains in patients with Parkinson’s disease…Clinical outcomes after DBS surgery in cognitively impaired patients with PD
Objective: To describe clinical outcomes after DBS in patients with PD and moderate cognitive impairment (CI). Background: DBS is generally contraindicated in PD patients with…Investigating Factors Contributing to Parkinson’s disease-related Cognitive Decline
Objective: The objective of this study was to identify predictive factors of cognitive decline in patients with Parkinson’s disease (PD). Background: Among those with PD,…Blood alpha-synuclein profile and lysosomal alterations distinguish GBA1-related Parkinson’s disease from sporadic Parkinson’s disease
Objective: This study aims to characterize blood profile of alpha-synuclein and the main lysosomal proteinsas well as clinical features of PD subjects carrying GBA1 mutations…NUS1 polymorphisms modify the risk and age at onset of Parkinson’s disease
Objective: In this study, using whole-exome sequencing (WES) and direct Sanger sequencing analysis, we investigated the common and low-frequency variants of NUS1 in two case-control…Whole exome trio analysis in isolated population of southeast Moravia (Czech Republic) with familial parkinsonism suggests its heterogeneous genetic background
Objective: The aim of the study was to identify shared genetic variants potentially associated with familial neurodegenerative parkinsonism using whole-exome analysis. Background: Increased prevalence of…Genome-wide association studies of progression in Parkinson’s disease
Objective: To identify genetic variants associated with composite (cross-domain), motor, and cognitive progression in Parkinson’s disease (PD). Background: Case-control genome-wide association studies (GWASs) in PD…
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