α-Synuclein propagation via olfactory pathway induces olfactory bulb atrophy and widespread glucose hypometabolism in a non-human primate model
Objective: We investigated how α-synuclein (α-Syn) pathology spreads from the olfactory bulb (OB) and how the pathology affects brain structure and activity. Background: Parkinson's disease…Identifying the functional brain network of motor reserve in early Parkinson’s disease
Objective: To explore the functional brain network associated with motor reserve in early-stage Parkinson’s disease (PD). Background: The severity of motor symptoms in PD does…Quantification of 123I-ioflupane Striatal Uptake and Individual Patient Diagnostic Predictions: Degenerative Parkinson’s disease, Non-Degenerative Parkinsonism and Tremor Disorders
Objective: To develop a fully automated quantitative method to analyse routinely acquired 123I-ioflupane (DaTSCAN) data to aid diagnostic predictions in patients with Parkinson’s disease, non-degenerative…Quantitative Susceptibility Mapping for Differential Diagnosis of Degenerative Parkinsonisms: A Comparison with Morphometric Indexes
Objective: To use a multimodal MRI approach for differential diagnosis of patients with degenerative parkinsonisms, comparing the diagnostic accuracy of Quantitative Susceptibility Mapping (QSM) data…Intrinsic Remodeling of the Fovea is Correlated with Contrast Sensitivity Loss in Parkinson’s Disease
Objective: The aim of the study was to determine a technical parameter of foveal pathology that is best suited for discriminating Parkinson’s disease (PD) eyes…The association between thinning of cerebral cortex and age of onset in Parkinson’s disease
Objective: This study is to clarify the differences of thinning in cerebral cortical areas in PD patients by age of onset. Background: It is well…Neuroimaging Extra-Striatal D2 Receptors in Parkinson’s Disease with Rapid Eye Movement Sleep Behaviour Disorder
Objective: Our aim was to characterize the extra-striatal dopamine in Parkinson’s disease (PD) with and without rapid eye movement sleep behaviour disorder (RBD) using in…Unraveling neural oscillatory changes due to STN Coordinated Reset Deep Brain Stimulation in the MPTP Non-Human Primate Model of Parkinsonism
Objective: To characterize the role of oscillatory neural changes and inter-regional synchronization in the pathophysiology of Parkinson's disease (PD), and in response to pharmacological- and…Lack of depotentiation may not be a hallmark of Levodopa-induced dyskinesias
Objective: Paired associative stimumlation (PAS)-induced plasticity, a form of spike-time dependent plasticity (STDP), is deficient in PD. We tested whether (1) PAS-induced plasticity could be…Pain syndrome in Parkinson’s disease: neurophysiological and MRI morphometric features
Objective: Investigation of the neurophysiological disorders and identify their structural correlates in the brain by MRI studies with using voxel-based morphometry to reveal subtle changes…
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