Molecular investigation of apparently healthy heterozygous Parkin mutation carriers
Objective: To investigate whether apparently healthy individuals carrying a heterozygous pathogenic Parkin (PRKN) mutation show molecular phenotypes of mitochondrial dysfunction. Background: Homozygous or compound-heterozygous mutations…CSF MicroRNA Analysis Reveals Angiogenesis And Autophagy Defects In Parkinson’s DiseasePatients
Objective: We investigated the effects of discoidin domain receptor (DDR)-1 inhibition on CSF miRNAs in Parkinson’s disease patients. Background: MicroRNAs (miRNAs) are post-transcriptional regulators of…Motor cerebro-cerebellar networks breakdown among different subtypes of Parkinson’s disease
Objective: The aim of this study was to investigate functional alterations within motor circuits of the cerebro-cerebellar system in tremor-dominant (TD) and postural instability and…Compensatory functional mechanisms of response inhibition in Parkinson’s Disease with impulse control disorders
Objective: To investigate response inhibition in Parkinson’s disease (PD) patients with impulse control disorders. Specifically, the neural underpinnings of two aspects of inhibition: proactive inhibition…The evaluation of the swallow tail sign in patients with parkinsonism or gait disorders
Objective: The goal of the study is to evaluate the reliability of swallow tail sign which claimed to be specific for Parkinson's disease. Background: Swallow…Clinical and transcranial sonography characteristics in benign phenotype of Parkinson’s disease.
Objective: To investigate clinical and transcranial B-mode sonography (TCS) characteristics of benign phenotype of Parkinson’s disease (bPD). Background: Parkinson’s disease (PD) progression is heterogeneous. A…Regional brain iron and gene expression variation in Parkinson’s disease
Objective: To shed light on the genes underlying increased cortical iron deposition in Parkinson’s disease (PD). Background: Oxidative stress secondary to brain iron accumulation is…Paradoxical cerebral hyperperfusion in Parkinson’s disease with orthostatic hypotension
Objective: This study manipulated the imaging modality to illustrate the physiology of cerebral flow with OH in PD (PD+OH). Background: Orthostatic hypotension (OH) may antedate…Decrease in STN high frequency activity after microelectrode insertion during DBS surgery for Parkinson’s disease
Objective: To examine the effects of microelectrode penetration into the STN on local field potential recordings in patients with PD undergoing bilateral STN DBS implantation.…Directional deep brain stimulation causes distinct intraoperative LFPs in Parkinson’s patients
Objective: To investigate the correlation between local field potential (LFP) evoked responses, recorded via the DBS lead in Parkinson’s disease patients to stimulation direction Background:…
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