Quantitative systems pharmacology modelling of Parkinson’s disease to compare anti-α-synuclein therapeutics
Objective: We previously constructed a quantitative systems pharmacology (QSP) model of Parkinson’s disease (PD) that combines pathogenesis and spatial propagation of misfolded α-synuclein (Asyn) [1].…Determination of the motor status after the implementation Levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease using a Machine learning Algorithm
Objective: Aim of this study was to develop a random forest (RF)-based PD model to determine the postoperative motor outcome at 2 years follow-up after…Directional steering in subthalamic deep brain stimulation for Parkinson’s disease: the Berlin experience
Objective: To review the use of directional current steering in a Berlin cohort implanted with segmented leads between 2016-2019. Background: The dorsolateral area of the subthalamic…Effects of Once-Daily Opicapone 50 mg on the Pharmacokinetics of Levodopa Administered as Carbidopa/Levodopa Extended-Release Capsules: An Open-Label Phase 1 Study
Objective: To assess the effects of opicapone 50 mg on the pharmacokinetics (PK) of levodopa (LD) and its metabolite, 3-O-methyldopa (3-OMD), when administered with oral…Levodopa/carbidopa intestinal gel (LCIG) reduces fluctuations and shortens time to on without troublesome dyskinesia in advanced Parkinson’s Disease: Post-hoc analyses of 54-week LCIG-monotherapy trial
Objective: To assess the long-term effectiveness of LCIG monotherapy on reducing daily health-state fluctuations and time to on without troublesome dyskinesia (ONwoTD) after waking Background:…Limitations of conventional dopaminergic medication in advanced Parkinson’s disease: results from 127 patients treated with Levodopa Carbidopa Intestinal Gel
Objective: To evaluate the characteristics of the last conventional dopaminergic treatments in a large cohort of patients with advanced Parkinson’s Disease (APD) treated with Levodopa…Unraveling the mechanisms of Tubulin Polymerization Promoting Protein TPPP/P25A degradation in oligodendrocytes
Objective: Our aim is to identify the proteolytic pathways responsible for the clearance of TPPP/P25A in oligodendrocytes, which may eventually represent potential therapeutic targets for…Endoscopic Characteristics of Dysphagia in Multiple System Atrophy compared to Parkinson’s Disease
Objective: This study systematically assessed phenotypes of dysphagia in MSA compared to PD and correlated subjective dysphagia to objective endoscopic findings in MSA. Background: Dysphagia…A retrospective review of clinical and MRI/CT radiological correlation in progressive supranuclear palsy (PSP)
Objective: To investigate the clinical and MRI/CT radiological correlation to improve the diagnosis and management of PSP Background: PSP is a rare progressive neurodegenerative disease…Clinical Outcomes in Parkinson’s with COVID 19 during the’ first wave’ in West Berkshire, United Kingdom (UK)
Objective: To review the outcomes of COVID 19 during the first wave in patients with Parkinson’s in West Berkshire, UK. Background: UK is one of…
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