CHAPERONIC PROPENSITIES OF AFRICAN WALNUT AS A THERAPEUTIC TARGET IN MANGANESE-INDUCED PARKINSON-LIKE NEUROPATHOLOGY IN WISTAR RATS
Objective: Herein, the chaperonic propensities of ethanolic extract of African walnut (WNE) in Manganese-induced Parkinson-like neuropathology in the prefrontal cortex and hippocampus was investigated. Background:…Alteration of lysosomal enzymatic activities in patients with multiple system atrophy
Objective: To estimate whether alteration of lysosomal activities contributes to synucleinophaties pathogenesis. Background: Multiple system atrophy (MSA) belongs to a group of neurodegenerative disorders termed synucleinopathies, which also include Parkinson's disease (PD)…Data-driven Subtype Classification of Patients with Early-stage Multiple System Atrophy
Objective: The objective of the present prospective study was to conduct latent class analysis (LCA) of a range of motor and nonmotor symptoms of MSA…Plasma microRNA expression profiling in patients with progressive supranuclear palsy. A five-microRNA panel in plasma was identified as a potential biomarker for progressive supranuclear palsy
Objective: Our objective was to identify differentially expressed, circulating miRNAs in PSP which could serve as diagnostic biomarker for this disease. Background: Progressive supranuclear palsy…Novel approach to MDS-UPDRS monitoring in clinical trials: Longitudinal Item Response Theory Models
Objective: Using the unique advantages of Item Response Theory (IRT), we developed unidimensional and multidimensional models to investigate non-tremor and tremor MDS-UPDRS Part 3 changes…“Striatal Hand Signs” and early diagnosis of Parkinson’s Disease: The “Monkey-Wrench Sign”.
Objective: To identify signs of hand deformations in PD patients with earlier diseases, and compare with intermediate and late phases patients. Background: “Striatal hand signs”,…Differentiating Gait Impairments in Early Parkinson’s Disease and Early Dementia with Lewy Bodies
Objective: To characterize and differentiate gait deficits early on in individuals with DLB and PD. Background: Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD)…Subjective cognitive complaints assessed with the cognitive domain of the Non-Motor Symptoms Scale predict longitudinal cognitive trajectory in people with Parkinson’s disease with normal cognition
Objective: To investigate whether subjective cognitive complaints assessed by the Non-Motor Symptoms Scale (NMSS) are predictive of longitudinal cognitive trajectories in cognitively intact people with…Initial longitudinal analyses of objectively assessed cognitive functional abilities in a cohort with Parkinson’s disease
Objective: Detect the earliest changes in cognitively demanding activities of daily living in Parkinson's disease (PD) and determine their relationship with changes in global cognition…Systematic review of cognitive subtypes derived from data driven approaches in Parkinson’s disease
Objective: To consolidate the current literature pertaining to cognitive subtypes derived using data-driven methods in Parkinson’s Disease (PD). Background: Recent application of the Mild Cognitive…
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