Premenstrual worsening of UPDRS motor scale in women affected by Parkinson’s Disease
Objective: The role of estrogen in dopaminergic pathways and the premenstrual worsening of parkinsonian symptoms. Background: Female sex hormones, during the menstrual cycle, could influence…Association of sex with health-related quality of life in adults with chronic tic disorders
Objective: To investigate if there was an association of sex with health-related quality of life (HR-QOL) and psychiatric comorbidities in adults with Tourette syndrome (TS)…Enrollment phase sensing data from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial
Objective: To describe enrollment sensing data from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) trial (NCT04547712). Background: Local field potential (LFP)…Subtyping Parkinson’s disease: Quality of life changes after subthalamic stimulation depend on nonmotor and motor symptoms
Objective: To investigate if patients with Parkinson’s disease (PD) undergoing subthalamic stimulation (STN-DBS) can be clustered in different subtypes based on demographic, motor and non-motor…Olfactory dysfunction as a predictor of the future development of parkinsonism in COVID patients
Objective: Olfactory dysfunction due to SARS-CoV-2 infection as a prodromal stage of PD. Background: Olfactory dysfunction due to SARS-CoV-2 disease can depend on the neuroinvasive properties…Effect of deep brain stimulation on dysphagia in Parkinson’s disease: A Systematic Review
Objective: To evaluate the effects of deep brain stimulation (DBS) on dysphagia in Parkinson's disease (PD) patients. Background: Although DBS in the subthalamic nucleus (STN)…Was the deep brain stimulation surgery successful? Is it the same for the physician and the patient ?
Objective: To compare the physician`s assessment and the patient perception of the definition of successful therapy in STN DBS. Background: Although the treatment of Parkinson's…LRRK2 Inhibition by BIIB122/DNL151 Demonstrates Robust Target and Lysosomal Engagement: Pharmacokinetics, Pharmacodynamics and Safety in Phase 1 and Phase 1b Studies in Healthy and Parkinson’s Participants
Objective: To characterize the pharmacokinetics (PK), pharmacodynamics, safety, and exposure-response (E-R) relationships of BIIB122/DNL151 to inform on clinical dose selection. Background: Increased LRRK2 kinase activity…Nucleus basalis of Meynert and total gray matter atrophy are related to cognitive and gait decline in Parkinson’s disease
Objective: To assess the associations between the nucleus basalis of Meynert (NBM) and total grey matter atrophy with cognitive phenotype and gait measures in a…PET visualization of α-synuclein pathologies in humans using [18F]C05-05
Objective: This study aimed to visualize α-synuclein aggregates in living patients with Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).…
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