Was the deep brain stimulation surgery successful? Is it the same for the physician and the patient ?
Objective: To compare the physician`s assessment and the patient perception of the definition of successful therapy in STN DBS. Background: Although the treatment of Parkinson's…LRRK2 Inhibition by BIIB122/DNL151 Demonstrates Robust Target and Lysosomal Engagement: Pharmacokinetics, Pharmacodynamics and Safety in Phase 1 and Phase 1b Studies in Healthy and Parkinson’s Participants
Objective: To characterize the pharmacokinetics (PK), pharmacodynamics, safety, and exposure-response (E-R) relationships of BIIB122/DNL151 to inform on clinical dose selection. Background: Increased LRRK2 kinase activity…Nucleus basalis of Meynert and total gray matter atrophy are related to cognitive and gait decline in Parkinson’s disease
Objective: To assess the associations between the nucleus basalis of Meynert (NBM) and total grey matter atrophy with cognitive phenotype and gait measures in a…PET visualization of α-synuclein pathologies in humans using [18F]C05-05
Objective: This study aimed to visualize α-synuclein aggregates in living patients with Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).…Differences in gray matter atrophy and functional connectivity between motor subtypes of Parkinson’s disease
Objective: This study compared gray matter volume (GMV) and functional connectivity among patients with Parkinson’s disease involving postural instability/gait difficulty (PD-PIGD), patients with tremor-dominant Parkinson’s disease (PD-TD) and healthy…Clinical and functional determinants of motor reserve in patients with de novo Parkinson’s disease
Objective: To determine the clinical determinants and the role of serotonergic innervation on motor reserve in patients with de novo Parkinson's disease. Background: Patients with…Bilateral staged MR-guided focused ultrasound thalamotomy for Essential Tremor: one-year follow-up results
Objective: To evaluate the safety and efficacy outcomes of bilateral staged magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy for medication-refractory essential tremor (ET) and ET…Effectiveness of speech therapy in patients with Parkinson’s disease – a randomized controlled trial
Objective: We aimed to assess the effectiveness of speech therapy on improving quality of life and speech quality in patients with Parkinson’s disease. Background: Although…London-Dhaka Parkinson’s Cognition Study: A collaboration to evaluate cognitive impairment in under-represented Parkinson’s disease patients
Objective: Our aim is to study the prevalence of cognitive impairment (CI) in a diverse group of people with Parkinson's disease (PwP) from East London,…Development and validation of a new wearable device for the differential diagnosis of resting tremor
Objective: To develop a new easy-to-use wearable device to estimate the muscular contraction pattern of rest tremor (RT) using inertial data. Background: The RT pattern…
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