Interlaboratory cross-validation of CSF α-synuclein seeding aggregation assay for parkinsonisms
Objective: To evaluate CSF α-syn-SAA interlaboratory reproducibility in diagnosing Parkinson´s Disease (PD) and atypical parkinsonisms as well as interrogate the effect of changes in lot…Clinical and Dopaminergic Characteristics of MSA-C Patients with Predominant Cerebellar Asymmetry
Objective: To identify multiple system atrophy–cerebellar type (MSA-C) patients with marked cerebellar asymmetry and compare their features with symmetrically affected patients. Background: While asymmetry is…Alpha-Synuclein Promotes the Expression and Release of Neurofilament Light Chain from Oligodendrocytes in Multiple System Atrophy
Objective: This study aims to determine the Neurofilament light chain (NfL) expression in oligodendrocytes, investigate whether excess α-synuclein (α-syn) impacts NfL expression, release, and functions…Conjugal Parkinsonism
Objective: To report a case of multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) in a couple. Background: Conjugal parkinsonism denotes an entity where…Brain Target Engagement and Pharmacokinetic-Enzyme Occupancy (PK-EO) Relationship of FNP-223: A Novel Oral OGA Inhibitor for Progressive Supranuclear Palsy – Phase 1 PET Study
Objective: To determine the brain O-GlcNAcase (OGA) occupancy, following a single oral dose of FNP-223 (formerly ASN90) and to determine PK-EO relationship. Background: Preclinical evidence…Exploring the Role of Aperiodic and Periodic Spectral Activity in Guiding Deep Brain Stimulation Electrode Selection for Childhood Dystonia
Objective: To evaluate the potential of aperiodic and periodic neural activity in guiding clinical deep brain stimulation (DBS) programming for children with dystonia. Background: DBS…Microstructural Changes in the Striatum Correlate With Clinical Symptoms in Wilson Disease
Objective: To evaluate microstructural changes in the dorsal striatum and their correlation with clinical symptoms in Wilson disease (WD). Background: Advanced diffusion models, including Neurite…Development of Gene Panel by Next‐Generation Sequencing Approach for Diagnosis of Paroxysmal Movement Disorders
Objective: To develop a targeted gene panel for Paroxysmal Movement Disorders using Whole Exome Sequencing. Background: Paroxysmal movement disorders (PMDs) are a neurological disorder, characterized…The Impact of Non-Invasive Brain Stimulation Timing on Physiotherapy Outcomes for Parkinson’s Disease a Systematic Review with Dose-Response Analysis
Objective: To determine the best timing for non-invasive brain stimulation (NIBS) intervention to enhance physiotherapy-induced motor recovery in patients with Parkinson's disease (PwPD), and to…Community Awareness of Parkinson’s Disease as a Driver of Stigma in Kilifi, Kenya
Objective: To gain a holistic understanding of stigma surrounding Parkinson’s disease in Kenya from the perspective of those who are stigmatised, and those who might…
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