Exploring Neuroprotective Role of Natural Compound by Targeting c-Abl Kinase in Parkinson’s Disease
Objective: To explore c-Abl kinase activation and neuron death pathway in Parkinson’s Disease (PD) mouse model. Assess neuroprotection natural compounds, Rosmarinic acid (RA) with proven…Sensory-motor striatum iron accumulation in patients with isolated rapid eye movement sleep behavior disorder and its correlation with processing speed performance
Objective: This study aims to examine iron deposition in striatum and substantia nigra pars compacta (SNc) functionally segmented in patients with isolated rapid eye movement…MultiModal Transformer-Based Detection of Parkinson’s Disease in fMRI Extracted Time Series
Objective: Develop and evaluate a multimodal, transformer-based pipeline for detecting Parkinson’s disease (PD) from resting-state fMRI time series, aiming to expose short-lived neural connectivity disruptions…STN Iron Content Correlates with DBS Efficacy in Parkinson’s Patients: a Preliminary Study
Objective: Evaluate the relationship between baseline iron levels in the subthalamic nucleus (STN) and their impact on motor function and dopaminergic medication needs after deep…LRRK2 Polymorphisms and Associations with Parkinson’s Disease in Participants of East Asian, Southeast Asian, and European Descent
Objective: To investigate the prevalence of LRRK2 polymorphisms, R1628P and G2019S, and their association with Parkinson’s Disease (PD) in cohorts of East Asian (EA), Southeast…Interrogating GCase Activity in Human Monocytes Isolated from Parkinson’s Disease Patients Carrying the Asian LRRK2 G2385R and R1628P Variants
Objective: To compare Glucocerebrosidase-1 (GCase) activity in human monocytes of manifesting LRRK2 G2385R, R1628P, and double-variant carriers vs. idiopathic Parkinson’s disease (iPD) and healthy controls…Insights into Genetic Counseling Recall and Clinical Trial Interest in PD GENEration
Objective: To assess the impact of participation in PD GENEration, a large-scale genetic and counseling study for Parkinson’s disease (PD). We evaluated the recall of…Artificial Intelligence Unveils Genetic Etiologies in Parkinson’s Disease: Cases Clustered by Clinical Features
Objective: The aim of this study is to explore whether artificial intelligence (AI) can accurately cluster Parkinson’s Disease (PD) patients carrying different variants in PD-associated…Association Between Hyperuricemia, Gout, and the Risk of Parkinson’s Disease: An Updated Systematic Review and Meta-Analysis
Objective: To explore and evaluate the association between gout, hyperuricemia, and Parkinson’s disease (PD) using a systematic review and meta-analysis, incorporating stratified analyses by age…Impact of rare lysosomal gene variants on Parkinson’s disease
Objective: To investigate the contribution of rare variants in lysosomal genes to Parkinson’s disease (PD) susceptibility. Background: Variants in the lysosomal gene GBA1 are established…
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