GBA1 deficiency promotes the spread of Lewy pathology
Objective: To elucidate how GBA1 deficiency promotes the spread of Lewy pathology from cell to cell. Background: Mutations in the gene glucosidase, beta acid 1 (GBA1) not…Combining Pharmaceutical and Digital Treatment Approaches in Parkinson’s Disease Modulates of the Limbic System, Supporting Emotional Regulation and Motivated Behaviors
Objective: Following the combination of standard levodopa treatment with a digital intervention in Parkinson's disease (PD), we assessed the associations between neuroplasticity within the limbic…Cerebello-Thalamo-Cortical Tract Microstructural Changes in Parkinson’s Disease Patients with Tremor
Objective: To evaluate microstructural characteristics in the cerebello-thalamo-cortical circuit (CTC) of Parkinson's Disease (PD) patients with different tremor phenotypes. Background: Tremor is one of the…Cholinergic activity associates with cognitive function in PD using [18F]VAT
Objective: To map the relationship between cholinergic activity in Parkinson Disease (PD) and cognitive performance and identify any differences in this relationship in cognitive impairment.…Whole Genome Sequencing of an Early-onset Malaysian Parkinson’s Disease Cohort
Objective: To investigate the genetic causes of Malaysian early-onset Parkinson’s disease (EOPD) patients with whole genome sequencing (WGS). Background: EOPD (age of diagnosis ≤50 years)…Inflammatory profile in LRRK2-associated prodromal and clinical PD:a cross-sectional study
Objective: To investigate the peripheral inflammatory cytokine levels and their associations with clinical severity, dopaminergic presynaptic degeneration in asymptomatic carriers and PD patients with LRRK2 mutation.To investigate…Smoking and Genetic Interactions in Parkinson’s Disease
Objective: To investigate the interaction between smoking and Asian-specific LRRK2 variants (G2385R and R1628P) in Parkinson’s disease (PD) risk, examining whether smoking modifies the genetic…A Case for Novel Phenotypes Associated with Digenic CHMP2B-LRRK2 Mutations
Objective: We report a patient presenting with both bv-FTD & PD phenotypes, alongside a complex family history featuring multiple neurodegenerative disorders. Background: The CHMP2B &…Building Genetic Counseling Capacity in Latin America: The PD GENEration–LARGE-PD Training Framework
Objective: The PD GENEration (PD GENE) study has expanded into Latin America through collaboration with the Latin American Research Consortium on the GEnetics of Parkinson's…Light-Based Therapy in Parkinson’s Disease: The Emerging Role of Optogenetics
Objective: This review explores the potential of optogenetics in Parkinson’s disease (PD) therapy, emphasizing its ability to address the limitations of current treatments like deep…
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