Alpha-Synuclein Accumulation-Attenuating Effect of Brain-Derived Neurotrophic Factor in Primary Cell Culture Model of Parkinson’s Disease
Objective: To explore the role of neurotrophic signaling pathways in modulating the effect of brain-derived neurotrophic factor (BDNF) on pre-formed fibrils (PFFs)- induced alpha-synuclein (aSyn)…Differential Effect of Dopaminergic Treatment on Bradykinesia Features and Limb-kinetic Apraxia in Parkinson’s Disease
Objective: To investigate the differential effects of dopaminergic therapy on bradykinesia and limb-kinetic apraxia in PD patients using kinematic analysis. Additionally, transcranial magnetic stimulation (TMS)…Effect of Exercise Intervention on Parkinson’s Disease Resting-State fMRI Functional Connectivity
Objective: Investigate the effects of exercise on resting-state (rs) fMRI functional connectivity (FC) in Parkinson’s Disease (PD). Background: Recent studies have shown strong clinical evidence…Patient-specific Vascularized Midbrain Assembloids with Microglia show Altered Neuroinflammatory Phenotypes in Parkinson’s Disease
Objective: This study aims to develop patient-specific vascularized midbrain assembloids incorporating microglia to better model the neuroinflammatory environment of Parkinson’s disease (PD). By integrating vascular…Detection and classification of Parkinson’s disease from neuroimaging modalities using machine learning and artificial intelligence: a systematic review
Objective: This systematic review evaluates performance of machine learning (ML) and artificial intelligence (AI) techniques applied to neuroimaging modalities in differentiating Parkinson’s disease (PD) patients…Striatal dopamine- and basal forebrain cholinergic-dependent brain metabolism and cognition in Parkinson’s disease
Objective: To explore the interrelation of striatal dopamine, cholinergic basal forebrain volume, brain metabolism, and cognition in PD. Background: Parkinson’s disease (PD) involves multiple neurotransmitter…Cerebral Glucose Metabolic Features of GBA-Parkinson’s Disease as a window into cognitive impairment
Objective: to investigate cerebral glucose metabolism via fluorodeoxyglucose positron emission tomography (FDG-PET) and its correlation to clinical features in Parkinson’s disease (PD) patients with GBA1…A Multi-Transcriptional Risk Score Approach to Parkinson’s Disease Prediction
Objective: To improve the prediction of Parkinson’s disease (PD) by examining aggregate profiles of gene expression in the form of transcriptional risk scores (TRS). Background:…Investigating the Global Genetic Spectrum of Monogenic Parkinson’s Disease and Parkinsonism
Objective: To investigate known pathogenic and risk variants linked to Parkinson’s disease (PD) at a global, multi-ancestry scale. Background: Genetic forms of PD have been…Mutations of the VPS13A gene in a patient with Early-Onset Parkinson’s Disease: A case report.
Objective: To describe the case of a patient with early-onset Parkinson's Disease (PD) with variants of the VPS13A gene. Background: The vacuolar protein sorting 13A…
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