Discordant Siblings Reveal Determinants of Clinical Penetrance in GBA-Associated Parkinson’s Disease
Objective: To investigate clinical, neuropsychological, biomarker, and imaging differences between siblings carrying the same GBA1 variant but discordant for Parkinson’s disease (PD). Background: Variants in…Psychosis in Parkinson’s Disease Patients Treated with Continuous Subcutaneous Foslevodopa/Foscarbidopa: A Real-World Observational Study.
Objective: To assess the incidence and timing of psychosis (hallucinations and delusions) in Parkinson’s disease patients receiving continuous subcutaneous infusion of foslevodopa/foscarbidopa (CSFLI). Background: CSFLI…Immunological characteristics of Parkinson’s disease by clinical form and stage
Objective: To analysed of IL-10 concentrations in serum of patients with PD. Background: IL-10 is a key pro-inflammatory cytokine involved in the regulation of microglia…Linking Motor and Non-Motor Fluctuations in Parkinson’s Disease
Objective: The aim of this study is to find a correlation between motor and non-motor symptoms fluctuation in parkinson’s disease. Background: Despite increasing awareness of…The Feasibility and Safety of Rehabilitation Program in Patients with Multiple System Atrophy
Objective: To evaluate the effects of rehabilitation on functional and clinical outcomes in patients with multiple system atrophy (MSA). Background: Currently, disease-modifying treatments for MSA…Risk factors and management of postoperative infection following deep brain stimulation – A single center experience
Objective: To investigate the incidence, risk factors, and management of DBS-related infections at a center in Vietnam. Background: Deep brain stimulation (DBS) is an established…Effects of Chronic IEM-1460 Treatment on Perineuronal Net–Parvalbumin Interneuron Association in L-DOPA-Induced Dyskinesia
Objective: To determine whether chronic IEM-1460 administration alters dyskinesia and perineuronal net (PNN)–parvalbumin interneuron (PV-IN) association in a 6-OHDA rat model of L-DOPA-induced dyskinesia (LID).…Intranasal Delivery of Berberine-Loaded Solid Lipid Nanoparticles Ameliorates Neuropathological and Behavioral Deficits in a Preclinical Alzheimer’s Model
Objective: To evaluate the pharmacokinetic profile and neuroprotective efficacy of intranasally administered berberine-loaded solid lipid nanoparticles (BE-SLN) in a streptozotocin (STZ)-induced rat model of Alzheimer’s…Genetic Modifiers of Age at Onset for Parkinson’s Disease in European Populations
Objective: To investigate genetic factors underlying age at onset (AAO) variability in PD in the largest diverse European cohort to date. Background: Genetic factors substantially…Latent Classes of Cognitive Decline in Parkinson’s Disease: Neuroimaging and Neurodegenerative Blood Biomarker Correlates
Objective: To identify longitudinal trajectories of cognitive decline in Parkinson’s disease (PD) and to characterize neuroimaging and neurodegenerative blood biomarker correlates. Background: Cognitive impairment affects…
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