Assessing Agreement of Self-Perception of Dysphagia in Individuals with Parkinson Disease and their Caregivers
Objective: To investigate the association of self-perception of dysphagia in individuals with Parkinson disease (IwPD) with their caregivers’ perceptions at early, mid and late stages…Distinct Non-Motor Symptom Progression Subtypes in Parkinson’s Disease Identified Using a Data-Driven SuStaIn Model
Objective: To identify progression-oriented non-motor symptom subtypes in PD using a probabilistic Subtype and Stage Inference (SuStaIn) model applied to routinely available clinical assessments. Background:…Bidirectional associations between seizures and parkinsonism: a retrospective case series
Objective: Within a single center, describe individuals with parkinsonism who develop seizures and vice versa based on epilepsy and movement disorders evaluation. Background: While neurodegeneration…Chronic Vanadium Exposure Promotes Memory Impairment and Aggregation of Alpha-Synuclein, Tau and Amyloid Beta in Mouse Brain
Objective: In this study, we hypothesized that prolonged vanadium exposure may be a potential risk factor for Alzheimer's and Parkinson's diseases. Background: The interaction between…Electroacupuncture Restores Cortico-striatal Synaptic Plasticity by Promoting STEP61 against 6-OHDA Induced Extrasynaptic NMDAR/TRPM4 Complex
Objective: This study investigated whether electroacupuncture (EA) exerted neuroprotection by regulating the physical coupling of extrasynaptic N-methyl-D-aspartate receptor (NMDAR) to the transient receptor potential (TRP)…Real-World Impact of “Off” Time Reduction with Foslevodopa/Foscarbidopa in Advanced Parkinson’s Disease: Post Hoc Analysis of the ROSSINI Study
Objective: Examine dyskinesia and quality of life (QoL) outcomes in patients experiencing meaningful clinical improvements in “off” time during treatment with foslevodopa/foscarbidopa (LDp/CDp). Background: Clinical…Multi-tracer positron emission tomography reveals early disruption of cerebrospinal fluid clearance in Huntington’s disease
Objective: To evaluate lateral ventricular (LV) positron emission tomography (PET) signal and choroid plexus (CP) volume as biomarkers of disease progression in Huntington’s disease (HD),…Oral D1-like/D2-like Receptor Agonist, Lu AF28996, Provides Robust Antiparkinsonian Efficacy with Reduced Dyskinesia in the MPTP-Macaque Model
Objective: Evaluate the therapeutic potential of Lu AF28996 in the MPTP-macaque model of PD. Background: Chronic levodopa treatment is associated with the development of motor…To Protect Life and Safeguard Autonomy: Ambiguous Expressions of the Will to Live
Objective: This study examines the ethical and legal criteria for determining a patient’s authentic will in late-stage Parkinson’s disease when refusal of life-sustaining measures occurs…Juvenile-Onset Parkinsonism With Bilateral Striatal Necrosis Associated With a Pathogenic MT-ND3 Mitochondrial Variant
Objective: To report a case of juvenile-onset parkinsonism associated with bilateral striatal necrosis and a pathogenic MT-ND3 mitochondrial DNA variant, emphasizing an atypical mitochondrial phenotype…
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