Isolation of Seeding Competent Material by Means of ThT Extraction
Objective: To develop a method for capturing α-synuclein (syn) seeds from cerebrospinal fluid (CSF) and other matrices with high affinity by means of thioflavin T…Salivary Biomarkers in Parkinson’s Disease: A Follow-Up Study
Objective: Investigate longitudinal changes in salivary levels of oligomeric and total a-synuclein (a-syn), phosphorylated-tau (p-tau), total tau, MAP-LC3, and TNFa in Parkinson’s Disease (PD) patientsAssess…α-Synuclein Triggers Neuroinflammatory Damage through the suppression of MEF2C
Objective: To explore the effects of microglial myocyte enhancer factor 2C (MEF2C) in neuroinflammation induced by α-synuclein. Background: The abnormal aggregation of α-synuclein (α-syn) is a critical…Analgesic Effect of Cannabidiol and Tetrahydrocannabinol(THC) on Pain Sensitivity in Reserpine Model of Parkinson’s Disease
Objective: The objectives of the study were to determine the effect of THC and CBD on:1. Thermal nociceptive threshold in reserpine induced Parkinson’s disease2. Mechanical…Developing a novel Disease-Specific iPSC Model for Studying MSA Pathogenesis
Objective: This study aims to develop a human iPSC-derived oligodendrocyte (iPSC-OL) model to investigate cell-specific disease mechanisms in MSA. Specifically, we seek to:a)Generate MSA patient-derived…GT-02287 in Parkinson’s Disease: Interim Data from a Phase 1b Study
Objective: To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the brain-penetrant glucocerebrosidase (GCase) modulator GT-02287 in people with Parkinson’s disease with and without a…The Syn-Sleep Study Detection of Cutaneous Phosphorylated Alpha-Synuclein in REM Sleep Behavior Disorder
Objective: The goals of this longitudinal, prospective study are 1) to determine rates of P-SYN deposition in RBD and quantify changes in PSYN deposition over…Amplification Parameters of the Alpha-Synuclein Seed Amplification Assay on CSF Predict the Clinical Subtype of Parkinson’s Disease at 10-Year Follow-Up
Objective: To assess the association between the parameters of alpha-synuclein seed amplification assay on CSF (CSF-αSyn-SAA) within 2 years from Parkinson’s disease (PD) onset and…Neuroprotective Effects of ATP6V0C Overexpression in PFF Model Mice
Objective: Elucidating the role of lysosomal dysfunction due to altered stability and expression levels of V-type proton subunit ATP6V0C in the degradation and propagation of…Prevalence of Supine Hypertension in Alpha-Synucleinopathies: a Systematic Review and Meta-Analysis
Objective: We aimed to conduct a systematic review and meta-analysis to assess the prevalence of supine hypertension (SH) in α-synucleinopathies. Background: Alpha-synucleinopathies, including Parkinson’s Disease…
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