Assessment of α-Synuclein Seeding Activity in the Olfactory Mucosa after SARS-CoV-2: a Pilot Study
Objective: To determine whether symptomatic SARS-CoV-2 infection is associated with local α-synuclein (aSyn) aggregation in the olfactory mucosa (OM) as measured by an aSyn seeding…Proximity Ligation Assay Reveals Early Tractopathy in Parkinson’s Disease
Objective: To determine how α-synuclein (αSyn) pathology extends beyond the neuronal soma in the anterior cingulate cortex (ACC) by mapping early pathological changes within adjacent…Regulatory architecture of the SNCA locus in Parkinson’s Disease: Characterization of reported functional mQTL variants in GP2
Objective: To characterize previously reported regulatory variants at the SNCA locus associated with DNA methylation by integrating methylation quantitative trait locus (mQTL) annotations with genotype-derived…Identification of Alpha-synuclein Pathology in Dementia with Lewy Body Participants by Seed Amplification Assay
Objective: To assess frequency and type of misfolded α-synuclein aggregates (syn-seeds) in cerebrospinal fluid (CSF) from dementia with Lewy bodies (DLB) participants by means of…Insight into α-synuclein pathogenicity by a human cell model with suppressed NatB-mediated N-terminal acetylation
Objective: Our aim was to study α-syn Nt-acetylation and its impact on the disease-relevant properties of this protein in cell models to shed light on…The Syn-Q Study: Quantification of phosphorylated alpha-synuclein in patients with Parkinson’s disease and REM sleep behavior disorder
Objective: To define changes in cutaneous P-SYN quantitation over 18 months in patients with Parkinson’s disease (PD) and isolated REM sleep behavior disorder (iRBD).To define…Multi-Modal Profiling of Peripheral and Central Nervous System T Cells Identifies Cytotoxic α-Synuclein-Reactive Immunity in Multiple System Atrophy
Objective: To define α-synuclein-specific peripheral T cell responses in multiple system atrophy (MSA) in comparison with parkinson’s disease (PD) and healthy controls (HC), and to…SAA Positivity Rate Amongst Dual LRRK2-GBA1, GBA1 and LRRK2 Carriers with Parkinson’s Disease
Objective: We investigated positivity rate in dual GBA1+LRRK2-PD by comparing GBA1+LRRK2-PD carriers(n=13), GBA1-PD(n=169) and LRRK2-PD(n=175). Background: GBA1 and LRRK2 variants represent the most common genetic…GBA1 deficiency promotes tau and TDP-43 co-pathology
Objective: To determine whether mutations in the gene beta-glucocerebrosidase 1 (GBA1), the strongest genetic risk factor for PD, promote tau and TDP-43 co-pathology alongside Lewy…Identification of Alpha-synuclein Pathology in Idiopathic Rapid Eye Movement Sleep Disorder Participants by Seed Amplification Assay
Objective: To assess correlations between cerebrospinal fluid (CSF) α-synuclein seed amplification assay (synSAA) and the phenoconversion rate, timing, and final diagnosis of idiopathic rapid eye…
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