Gene-Caffeine Interaction in Parkinson’s Disease: A Case-Control Study of Alpha-synuclein SNPs
Objective: Investigating the interaction between genetic susceptibility and caffeine intake in modulating Parkinson’s disease (PD) risk. Background: PD arises from a complex interplay of genetic…A rapidly progressive multiple system atrophy-cerebellar variant model presentingα-synuclein oligomer spreading and phosphorylated α-synuclein aggregate formation accompanied with glial inflammation
Objective: We aimed to develop a rapidly progressive mouse model that recapitulates MSA-C pathology. Background: Multiple system atrophy (MSA) is a severe α-synucleinopathy driven by…Screening for Neuronal Synuclein Disease (NSD) using cerebrospinal fluid (CSF) in the Parkinson Progression Marker Initiative (PPMI)
Objective: To utilize a centralized screening paradigm for early stage NSD based on sequential olfactory dysfunction (measured by University of Pennsylvania Smell Identification test (UPSIT))…Isolation of Seeding Competent Material by Means of ThT Extraction
Objective: To develop a method for capturing α-synuclein (syn) seeds from cerebrospinal fluid (CSF) and other matrices with high affinity by means of thioflavin T…Salivary Biomarkers in Parkinson’s Disease: A Follow-Up Study
Objective: Investigate longitudinal changes in salivary levels of oligomeric and total a-synuclein (a-syn), phosphorylated-tau (p-tau), total tau, MAP-LC3, and TNFa in Parkinson’s Disease (PD) patientsAssess…α-Synuclein Triggers Neuroinflammatory Damage through the suppression of MEF2C
Objective: To explore the effects of microglial myocyte enhancer factor 2C (MEF2C) in neuroinflammation induced by α-synuclein. Background: The abnormal aggregation of α-synuclein (α-syn) is a critical…Analgesic Effect of Cannabidiol and Tetrahydrocannabinol(THC) on Pain Sensitivity in Reserpine Model of Parkinson’s Disease
Objective: The objectives of the study were to determine the effect of THC and CBD on:1. Thermal nociceptive threshold in reserpine induced Parkinson’s disease2. Mechanical…Developing a novel Disease-Specific iPSC Model for Studying MSA Pathogenesis
Objective: This study aims to develop a human iPSC-derived oligodendrocyte (iPSC-OL) model to investigate cell-specific disease mechanisms in MSA. Specifically, we seek to:a)Generate MSA patient-derived…GT-02287 in Parkinson’s Disease: Interim Data from a Phase 1b Study
Objective: To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the brain-penetrant glucocerebrosidase (GCase) modulator GT-02287 in people with Parkinson’s disease with and without a…The Syn-Sleep Study Detection of Cutaneous Phosphorylated Alpha-Synuclein in REM Sleep Behavior Disorder
Objective: The goals of this longitudinal, prospective study are 1) to determine rates of P-SYN deposition in RBD and quantify changes in PSYN deposition over…
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