Dysregulation of lysosomal lipid microdomains impairs autophagic flux in GBA-associated Parkinson’s disease
Objective: To investigate the link between lipid dysregulation and lysosomal dysfunction in GBA-associated Parkinson’s disease (GBA-PD) and explore potential metabolic rescue strategies. Background: Mutations in the GBA gene…A Pilot Study of Phosphorylated Alpha-Synuclein Detection and Quantitation from Routine Colonic Biopsies in Patients with Parkinson’s disease
Objective: To develop a novel method for the detection of P-SYN within superficial colon biopsies that can be obtained during routine colonoscopy. Background: Parkinson’s disease…Diagnosing Prodromal Synucleinopathies – What is the Role of Cardiac MIBG Scintigraphy?
Objective: We aimed to characterize cardiac MIBG uptake patterns in patients with an initial diagnosis of PAF (iPAF) and assess their role as a prognostic…Skin Biopsy for Phosphorylated Alpha-Synuclein and DAT Imaging in Patients Diagnosed with Psychogenic Parkinsonism
Objective: Objective:Describe the results of skin biopsy for phosphorylated alpha-synuclein (P-SYN) and dopamine transporter (DAT) imaging in patients previously diagnosed with psychogenic parkinsonism (PP) and…A novel pro-drug overcomes short-half life and absorption challenges and increase brain penetration of dopamine as a potential therapy for Parkinson’s disease
Objective: We developed a new small molecule drug candidate that would increase the effectiveness of dopamine delivery to the brain. We also sought to mitigate…ALPHA-FIT: Slowing cognitive decline in alpha-synucleinopathies by enhancing physical activity
Objective: To evaluate the effects of increased physical activity on cognitive decline in patients with isolated REM sleep behavior disorder (iRBD). Background: Physical activity has…Patient-Derived α-Synuclein Kinetic Subtypes Drive Distinct Pathological Propagation Patterns and Brain Network Alterations in Parkinson’s Disease Mouse Models
Objective: To validate whether patient-derived α-synuclein (α-Syn) aggregates with distinct kinetic properties produce differentiated pathological propagation patterns, brain network functional alterations, and behavioral phenotypes in…The Syn-D Study: Detection of Longitudinal Changes in Cutaneous Phosphorylated Alpha-Synuclein in Mild Cognitive Impairment
Objective: To quantify the deposition of cutaneous phosphorylated alpha-synuclein (P-SYN) and plasma P-Tau217 in patients with mild cognitive impairment (MCI) due to suspected Alzheimer’s disease…Disassembly of α-Synuclein Aggregates by the All-D-peptide PRI-101: Preclinical Efficacy in Vitro and in Vivo.
Objective: To develop a disease-modifying therapy for Parkinson’s disease (PD) and related synucleinopathies by eliminating intracellular, toxic, and seeding-competent aggregate species of α-synuclein (α-syn). Background:…SCA27B and MSA-C with Positive Alpha-Synuclein Skin Biopsy – Case Report
Objective: To present the first reported case of Spinocerebellar Ataxia 27B (SCA27B) and clinically probable Multiple System Atrophy-Cerebellar subtype (MSA-C) with skin biopsy positive for alpha synuclein. Background: SCA27B is…
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