Longitudinal Cortical Changes Associated with Apathy in Parkinson’s Disease
Objective: To follow clinical/cognitive and cortical thickness (CT) changes in Parkinson’s disease (PD) patients with stable apathy (PD-sAp), without apathy (PD-noAp), and patients who developed…Quality of Life in Parkinson’s Disease: Impact of Depression and Apathy
Objective: The aim of this study is to investigate whether depression and apathy are independently related to QoL in patients with PD. Therefore, we performed…Fatigue and depression are predictors of the tremor form of Parkinson’s disease
Objective: The principal objective is to study the relationship between fatigue and depression with the peculiarities of the progress of PD. Background: Parkinson's disease (PD)…Apathy in Parkinson’s disease is associated with abnormal alpha oscillatory behaviour during incentivized movement
Objective: To determine the relation between apathy and neural oscillations in Parkinson’s disease (PD). Background: Apathy in PD, characterized by lack of motivation, is often…Impaired performance on measures of goal-directed behavior are associated with greater caregiver burden in Parkinson’s disease
Objective: To assess the utility of the Philadelphia Apathy Computerized Task (PACT) in measuring goal-directed behavior in Parkinson’s disease (PD). Background: Impairment in goal-directed behavior…Disrupted Amplitude of Low-frequency Fluctuations and Causal Connectivity in Parkinson’s Disease with Apathy
Objective: We aimed to explore associated neural substrates changes in Parkinson’s disease (PD) with apathy via amplitude of low-frequency fluctuations (ALFF) and Granger Causality Analysis…Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the raphe nuclei
Objective: To investigate whether apathy is related to serotonin depletion in the raphe nuclei in patients with rapid eye movement sleep behaviour disorder (RBD), a…Depression, apathy, fatigue in Parkinson with or without STN DBS
Objective: To determine the prevalence of depression, evaluate the relationship between depression, apathy and fatigue, and the impact of STN DBS on the same symptoms.…Perry syndrome: Proposal of international diagnostic criteria and a new disease concept
Objective: To propose international diagnostic criteria for Perry syndrome and a new disease concept. Background: Perry syndrome is a rare autosomal dominant neurodegenerative disease characterised…Impact of SYN120 (a Dual 5-HT6/5-HT2A antagonist) on psychiatric symptoms in patients with Parkinson’s disease dementia: Results from a Phase 2a Study
Objective: To assess the psychiatric effects of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is a dual antagonist of serotonin (5-HT6 and…
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