A Novel Homozygous Variant in MYORG is Associated with Primary Brain Calcification and Paroxysmal Dyskinesia
Objective: To report a novel homozygous MYORG mutation causing primary brain calcification (PBC) with paroxysmal dyskinesia and evaluate its functional pathogenicity. Background: PBC is a monogenic…Methanol Intoxication Presenting as a Mixed Ataxic-Parkinsonian Syndrome With a Paradoxical Response to Levodopa: A Case Report
Objective: To report a case of methanol-induced mixed cerebellar and parkinsonian sequelae, emphasizing the pathophysiological mechanisms underlying the neuroimaging findings and the paradoxical response to…Basal Ganglia Pathway Recruitment Determines Bidirectional Bradykinesia Modulation by DBS in Humans
Objective: Understanding the role of distinct basal ganglia pathways in DBS-elicited modulation of bradykinesia across its indications. Background: Opposing bidirectional effects of selective pathway stimulation…Quantitative Assessment of Turning Kinematics and its Association with Parkinson’s Disease Severity
Objective: This study aims to investigate the association between turning performance and disease severity, measured by the MDS-UPDRS and PDQ-39, in people with Parkinson’s disease…Organoid-Based AI Clinical Trial Platform for Phase 0 Studies in Parkinson’s Disease
Objective: we developed an organoid-based AI-driven platform to classify patient specific molecular subtypes and predict drug efficacy through an AI-powered validation pipeline. Patient-derived induced pluripotent…Saccadic mask-induced inhibition in Parkinson’s disease
Objective: To investigate the role of the substantia nigra pars reticulata (SNr) in saccadic mask-induced inhibition in Parkinson's disease. Background: Saccadic mask-induced inhibition (SMII) delays…Long-term analysis of subthalamic local field potentials (LFP) in Parkinson’s disease: Insights into circadian rhythms, medication, and personalized treatment effects
Objective: investigate electrophysiological patterns related to circadian rhythms, medication intake & long-term DBS effects. Background: Deep brain stimulation (DBS) offers substantial and long-lasting motor improvements…Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2023: A National Analysis pre and post COVID
Objective: To examine the trends and impact of COVID-19 on Parkinson’s disease (PD) mortality stratified by gender, race and region among older adults in the…Decoding Parkinson’s Progression: Longitudinal Volumetric MRI Biomarkers in Prodromal and Clinical Stages
Objective: This study investigates MRI volumetric analysis via VBM as a biomarker for early PD detection, focusing on structural alterations in deep gray matter regions…Machine Learning Analysis of DTI-Derived Free Water Reveals Distinct Parkinson’s Disease Subtypes: A Two-Year Longitudinal Study
Objective: To identify distinct subtypes of Parkinson’s disease (PD) based on diffusion tensor imaging (DTI)-derived free water (FW) patterns in basal ganglia (BG) structures using…
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