Does COMT Play a Role in Parkinson’s Disease Susceptibility Across Diverse Ancestral Populations?
Objective: To investigate the relationship between COMT genetic variants and PD risk across diverse ancestries. Background: The enzyme catechol-O-methyltransferase (COMT; OMIM:116790) plays a crucial role…Compensatory Dynamic Brain Network Mechanisms in Early Lewy Body Dementia: An rs-fMRI Study
Objective: To investigate compensatory dynamic brain network mechanisms in early Lewy body dementia (LBD), specifically mild cognitive impairment with Lewy bodies (MCI-LB), using resting-state functional…Subdomain-specific cognitive decline and its effect on caregiver burden in Mexican population living with Parkinson’s Disease.
Objective: To determine whether different subdomains of the MoCA associate with caregiver burden. Background: Caregivers improve the quality of life for Parkinson's patients (PwP), despite…Role of APOE Polymorphism and CSF Markers of AD Co-Pathology in the Cognitive Trajectories of Sporadic and Genetic Parkinson’s Disease: A Longitudinal Cohort Study
Objective: To evaluate if APOE genotype and CSF biomarkers of AD co-pathology are associated with distinct rates of cognitive decline in PD subtypes. Background: Cognitive…Neurophysiological research on inhibitory processes in Parkinson’s disease
Objective: To explore neural mechanisms of inhibitory control, specifically differentiating reactive from prepared inhibitory processes, by synthesizing recent intracranial EEG (iEEG) studies and neurophysiological research…A Four-Arm Randomized Controlled Trial on the Effects of Multi-Dimensional Cognitive Intervention in Parkinson’s Disease with Mild and Subjective Cognitive Decline (REMIND)
Objective: To investigate the efficacy of online Brain and Body Rehab Training (BBRT) (Figure 1), a digital cognitive intervention, in Parkinson’s disease patients with mild…Global Cognition Influences Non-Tremor Motor Decline in Parkinson’s Disease
Objective: To explore the longitudinal association between global cognition and i) global motor, ii) tremor, and iii) non-tremor motor severity and progression. Background: Impaired voluntary movement…Prevalence and Characteristics of Glucocerebrosidase Genetic Variants in Nepalese Early-onset Parkinson’s Disease Patients
Objective: To evaluate the genotype and phenotype of early-onset Parkinson´s Disease (EOPD) in the Nepalese population. Background: A significant proportion of early-onset PD (EOPD) can…Absence of identifiable neuropathological correlates of cognitive impairment in multiple system atrophy
Objective: To analyze neuropathological correlates of cognitive impairment in multiple system atrophy (MSA) and characterize the affected cognitive domains. Background: Current MSA census criteria delineate…PHIT-Brain Study Protocol: Adaptation and Evaluation of a Multifaceted Brain Health Intervention for Patients with Parkinson’s Disease and Mild Cognitive Impairment (PD-MCI)
Objective: The aim is to adapt a brain health program for the PD population, the Parkinson’s Health Initiative for Thinking and the Brain (PHIT Brain),…
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