Serum Based biomarkers in Parkinson’s disease with and without cognitive deficits.
Objective: To examine levels of putative biomarker proteins viz., neuronal pentraxin receptor (NPTXR), carnosine dipeptidase-1 (CNDP1), dickkopf-3 (DKK3) in the serum of Parkinson’s Disease patients…Timing of Deep Brain Stimulation and Cognitive Trajectories in GBA1-associated Parkinson’s Disease
Objective: This study focuses on the timing of DBS in relation to PD onset and explores cognitive trajectories across different GBA1 variant classes, with a…Longitudinal Association Between Baseline CSF GFAP Levels and Clinical Progression in Parkinson’s Disease A PPMI Study
Objective: To investigate whether baseline cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) levels predict changes in cognitive performance (MOCA) and motor severity (UPDRS) over…Circadian Regulator REV-ERBα Drives Microglial Lipid Metabolic Reprogramming and Cognitive Impairment in Parkinson‘s Disease
Objective: To investigate the mechanisms by which sleep disturbance exacerbates motor and cognitive deficits in Parkinson’s disease (PD), and to determine how alterations in the…Can digital Mobility Outcomes differentiate cognitive impairment in Parkinson’s Disease?
Objective: To determine if digital mobility outcomes (DMOs) differentiate between those with and without cognitive impairment in Parkinson’s disease (PD). Background: Cognitive impairment is common…Cognitive Safety and Stability in DBS for Parkinson’s Disease: Evidence for the Inclusion of Patients with Baseline Mild Cognitive Impairment.
Objective: Investigate the cognitive safety of Deep Brain Stimulation (DBS) in PD patients with baseline pre-operative diagnosis of Mild Cognitive Impairment (MCI) Background: DBS is…Early Caudate Dopaminergic Loss as an Imaging Biomarker of Cognitive Impairment in Parkinson’s Disease: A Longitudinal Analysis
Objective: The primary objective was to determine whether early pre-synaptic caudate denervation, measured using 123 I ioflupane SPECT quantitative metrics, provides independent and incremental prognostic value…Subregional Striatal Dopaminergic Deficits, Cerebral Hypoperfusion and Cognitive Impairment in Parkinson’s Disease
Objective: To investigate the associations of subregional striatal dopaminergic deficits with regional cerebral blood flow (CBF) and cognitive impairment in patients with Parkinson’s disease (PD).…Association of Coffee Consumption and Smoking with Cognitive Function in Patients with Early Parkinson’s Disease
Objective: This study investigated cognitive differences among patients with early-stage Parkinson's disease (PD) according to coffee consumption and smoking status. Background: PD is frequently accompanied…Sex-Specific Associations of APOE ε4 with Cognitive Decline in Parkinson’s Disease: Insights from the Critical Path Institute GEM-PD Initiative
Objective: We aim to advance precision medicine strategies for Parkinson’s disease (PD) through data-driven research led by the Critical Path for Parkinson’s (CPP) global public-private…
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