Clinical, Neurophysiological, and Biological Insights into Levodopa-Induced Dyskinesias
Objective: The aim of this study was to determine the clinical, neurophysiological and biological features of Parkinson's Disease (PD) patients with L-Dopa-induced dyskinesias (LIDs). Background:…Synaptic density and α-synuclein oligomers in skin biopsies: differences between idiopathic and GBA-linked Parkinson’s disease
Objective: To compare α-synuclein oligomers and synaptic density (SD) in skin biopsies from PD and GBA-PD. Background: Previous research [1] reported α-synuclein oligomers within synaptic terminals of autonomic fibers in…A case of idiopathic lower limb dystonia treated with combined use of botulinum toxin type A and phenol nerve block
Objective: Here we report a case of focal LLD successfully treated with combined botulinum neurotoxin type A (BoNTA) and Nerve block (NB). Background: Among focal dystonias,…Ultrasound-guided selective diagnostic nerve block in patients with elbow spasticity: a retrospective pilot study.
Objective: To evaluate efficacy and patients’ perception of the ultrasound-guided selective diagnostic nerve block (DNB) of the motor branch for brachialis muscle compared with the…Fundamental changes in Nerve Conduction Velocity and hyperpolarization latency of action potential of Sciatic nerve at the pre-motor phase in a chronic PD in vivo model: a neurotool for Parkinson’s disease diagnosis
Objective: To evaluate the changes in NCV and hyperpolarization latency of action potential of Sciatic nerve at the pre-motor phase in MPTP induced chronic PD…Comparison of Disease Progression in Patients with Brain-first versus Body-first Parkinson’s Disease
Objective: This study aimed to compare the clinical progression between brain-first and body-first PD groups using cardiac sympathetic denervation (CSD). Background: Brain-first and body-first Parkinson’s…Limb myorhythmia treated with chemodenervation: A case report
Objective: To describe the case of a patient with limb myorhythmia successfully treated with bolutinum toxin injections. Background: Myorhythmia is a rare condition characterized by…Does autosomal recessive Parkinson’s Disease behave as “Brain-first” subtype?
Objective: The aim of this study is to explore whether monogenic PD (due to parkin or DJ-1 homozygous mutations) can be subtyped as "brain-first" by…Lateralization of cochlear dysfunction as a specific biomarker of Parkinson’s disease; role for cholinergic transmission?
Objective: To understand to what extent an early cochlear dysfunction may represent an additional non-motor signature of Parkinson’s disease (PD) patients. Further, whether it may…Autonomic features in E46K-SNCA carriers
Objective: To evaluate structural and functional integrity of small autonomic nerve fibers and phosphorylated alpha-synuclein (p-syn) deposition in the skin of E46K-SNCA carriers as compared…