Fundamental changes in Nerve Conduction Velocity and hyperpolarization latency of action potential of Sciatic nerve at the pre-motor phase in a chronic PD in vivo model: a neurotool for Parkinson’s disease diagnosis
Objective: To evaluate the changes in NCV and hyperpolarization latency of action potential of Sciatic nerve at the pre-motor phase in MPTP induced chronic PD…Lateralization of cochlear dysfunction as a specific biomarker of Parkinson’s disease; role for cholinergic transmission?
Objective: To understand to what extent an early cochlear dysfunction may represent an additional non-motor signature of Parkinson’s disease (PD) patients. Further, whether it may…Autonomic features in E46K-SNCA carriers
Objective: To evaluate structural and functional integrity of small autonomic nerve fibers and phosphorylated alpha-synuclein (p-syn) deposition in the skin of E46K-SNCA carriers as compared…FUNCTIONAL MOTOR SYMPTOMS IN PARKINSON’S DISEASE, AND FUNCTIONAL PARKINSONISM: A SYSTEMATIC REVIEW
Objective: This following review aims to clarify the link between functional and organic parkinsonism, in order to improve the understanding of functional symptoms in PD.…Usefulness of Cardiac MIBG Scintigraphy, DAT scan and midbrain/pontine ratio to differentiate Parkinson disease from atypical parkinsonian syndrome
Objective: The purpose of this study was to evaluate the usefulness of cardiac 123I-metaiodobenzylguanidine (MIBG) uptake, Dopamine transporter (DAT) scan and midbrain/pontine ratio (M/P ratio)…Does dopaminergic denervation of specific anatomical regions of the basal ganglia correlate with clinical features of Parkinsonism: A quantitative DaTscan study
Objective: To correlate different clinical features of parkinsonism with regional variations of presynaptic dopaminergic dysfunction of the basal ganglia using quantitative DaTscans. Background: DaT-SPECT imaging…Is Heart Rate variability a differential biomarker in REM sleep behavior disorder, Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy?
Objective: Heart rate deceleration capacity (DC) and heart rate variability index (HRVI) as potential biomarkers for autonomic dysregulation were studied in subjects (each group N=10)…Evaluation of SV2A expression with [18F]MNI-944 PET imaging in healthy controls (HC) and Parkinson disease (PD)
Objective: To evaluate [18F]MNI-944, a highly selective synaptic SV2A PET imaging tracer, as a biomarker for longitudinal studies in early PD. Background: PD symptoms manifest…Alpha-synuclein aggregates of cardiac sympathetic nerves in synucleinopathies and in neurologically unimpaired subjects. Correlation with sympathetic denervation
Objective: To study the cardiac sympathetic innervation and its relationship with the incidence of alpha-synuclein deposits in heart tissue of synucleinopathies and asymptomatic control patients.…Effect of intra-striatal 6-OHDA lesion on extra-striatal structures in the mouse
Objective: Characterization of extra-striatal manifestations in the 6-hydroxydopamine (6-OHDA) Parkinson's disease (PD) animal model. Background: PD is a neurodegenerative disorder characterized by progressive loss of…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.