Effects of Manual Therapy on Hand Dexterity in Children Aged 4–8 Years: A Prospective Interventional Study
Objective: This study aimed to evaluate the effect of a structured manual therapy program on hand dexterity in young children. Background: Impaired hand dexterity is…Advancing Regular Non-motor Symptom Reporting During Inpatient Parkinson’s Disease Care Using a Self-Developed Digital Diary: A Three-Cohort Engagement Evaluation
Objective: To establish a robust digital approach that encourages hospitalized Parkinson’s disease (PD) patients to self-report non-motor symptoms throughout inpatient care, and to determine whether…Novel associations of VPS13C with phenotype and conversion of idiopathic REM sleep behavior disorder
Objective: We aimed to examine the role of VPS13C in the risk of iRBD and its association with α-synucleinopathy. Background: While VPS13C is a recessively…Clinical Relevance of Oral Health Assessment in Parkinson’s Disease Monitoring
Objective: To evaluate the clinical relevance of oral health assessment in Parkinson’s disease (PD) by determining whether oral inflammatory, microbial, and periodontal alterations are associated…Smartphone Video-Based Finger Tapping Analysis Using Machine Learning for Parkinson’s Disease Classification
Objective: To evaluate the accuracy of a machine learning model using smartphone-captured finger tapping videos to distinguish patients with Parkinson's disease (PD) from healthy controls…Novel Modeling Approach for Comparing Treatment-Naive and Post-Treatment Neuronal Synucleinopathy Progression Using Multi-Modal PPMI Data
Objective: To characterize multi-domain progression over the course of Neuronal alpha-Synuclein Disease (NSD), in both treatment-naive and treated individuals. Background: Neuronal alpha-Synuclein Disease (NSD), a…Clinical Evaluation of TT-P34: Exploring Safety and CSF Exposure in Parkinson’s Disease Patients
Objective: Evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of TT-P34 in cerebrospinal fluid (CSF) following multiple subcutaneous (SC) doses in Parkinson’s disease patients…Development and Testing of a Smartphone Application to Capture Patient-Centered Outcome (PCO) Measures for Dystonia
Objective: Develop a smartphone application to collect patient-centered outcome (PCO) measures for dystonia. Background: PCO measures tailored for each major adult-onset focal dystonia subtype (Cervical…Caregiver and Patient perspectives on Parkinson’s Disease at tertiary, urban teaching hospital in Zambia, Africa: A Focus Group Study
Objective: Conduct focus groups to better understand the lived experience of Parkinson's Disease (PD) patients and caregivers in Zambia. Background: PD is a global neurological disease with…Monitoring Parkinson’s Disease in the Dental Chair
Objective: Our goal is to bridge the mechanistic knowledge gap on the Microbiota-Gut-Oral-Brain-Axis (MGOBA)’s role in Parkinson’s disease (PD) pathogenesis through a case-control, proof-of-concept, observational…
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