Metabolic Covariance Networks in Progressive Supranuclear Palsy Revealed by Spatial independent component analysis
Objective: The study aims to apply S-ICA to 18F-fluorodeoxyglucose (FDG) data in progressive supranuclear palsy (PSP) patients, identifing PSP-specific independent metabolic covariate networks. We also…Putaminal dopamine modulates movement motivation in Parkinson’s disease
Objective: To investigate the quantitative effect of dopamine depletion on the motivation of motor effort in Parkinson’s disease. Background: The relative inability to produce effortful…Dopaminergic alterations in patients with Alzheimer’s disease
Objective: The objective of this study was to conduct a meta-analysis to determine the pooled mean difference (MD) in dopaminergic measures between Alzheimer’s disease and…Criteria Defining Chronic Pain Associated with Parkinson Disease
Objective: To assess the factors defining the association of chronic pain (>3 months) with PD. Background: Non-motor symptoms can be often associated with Parkinson disease…Comorbidity of schizophrenia and Parkinson’s disease: a clinical case report
Objective: To describe the case of a patient with paranoid schizophrenia followed by the onset of the Parkinson’s disease at the 44-year age Background: Currently…Characterizing Dopaminergic Correlates of Depression in Parkinson’s Disease: The PPMI Cohort
Objective: We explored the association between cerebrospinal fluid (CSF) dopamine metabolites and transporter denervation in the development of depression in Parkinson Disease (PD). Background: Depression…Pharmacological neuromodulation with intracerebroventricular administration of anaerobic dopamine for Parkinson’s disease
Objective: To assess the continuous intracerebroventricular (i.c.v.) of A-dopamine in patients with a telemetry-controlled intra-abdominal pump system connected to a subcutaneous catheter implanted through the…The Effect of Modulating Alpha-synuclein Aggregation on Clinical Outcome in the Presence of Standard-of-care Dopaminergic Therapy in Parkinson’s Disease. A Quantitative Systems Pharmacology Approach.
Objective: Understanding the biological link between alpha-synuclein biomarker changes and clinical outcome using computer simulation. Background: A number of disease modifying therapeutic interventions focused on…Ventral tegmental deep brain stimulation does not influence risk-taking behaviour in a standard gambling task
Objective: We here used a standard gambling task that involved risky decision-making. This permitted us to measure the effects of ventral tegmental area (VTA) deep…Parkin Coregulates Glutathione Metabolism in Adult Brain to Contribute to Redox Homeostasis
Objective: We sought to determine whether the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis in vivo. Background: The mechanisms by which…
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