Distinct FDG-PET metabolic patterns and connectivity alterations in dopamine transporter-deficient versus -preserved MSA-C
Objective: In this study, we stratified MSA-C patients by DaT-PET binding status (preserved vs deficient) and compared their 18F-FDG PET metabolic patterns and inter-regional metabolic…Coupling of Cholinergic and Dopaminergic Terminal Loss in Progressive Supranuclear Palsy: A Multimodal [18F]FEOBV and [11C]PE2I Study
Objective: To describe the relationships between dopaminergic and cholinergic terminal deficits in Progressive Supranuclear Palsy (PSP) relative to age-matched Normal controls (NC). Background: There is…Dopamine and Na,K-ATPase: Mechanisms of Direct Enzyme Modulation in the Hippocampus
Objective: This study aimed to investigate the direct effect of dopamine on Na,K-ATPase activity in rat hippocampal membranes and to determine whether this effect depends…Association of DAGLB Variants with Early-Onset Parkinson’s Disease Across Populations
Objective: Here, we investigated the contribution of DAGLB variants to PD across diverse ancestries using large-scale data from the Global Parkinson’s Genetics Program (GP2). Background:…In Silico Investigation of Dopamine Receptor–Calcium Channel Coupling in Subthalamic Nucleus Neurons: Implications for Parkinson’s Disease Therapy
Objective: Parkinson’s disease (PD) is characterized by disrupted dopaminergic signaling within the basal ganglia circuitry, particularly affecting the activity of subthalamic nucleus (STN) neurons [1,…Dopaminergic Modulation Of Contextual Emotional Appraisal And Shame In Parkinson’s Disease
Objective: To investigate the influence of dopaminergic replacement therapy (DRT) on emotional appraisal and shame-related responses in PD patients with fluctuations. Background: Shame and embarrassment…Dopamine depletion does not mitigate striatal reward prediction error signals
Objective: To elucidate the role of dopamine in computing reward prediction error signals in the basal ganglia Background: Phasic discharges of midbrain dopamine neurons are…R1 from 18PR04.MZ as a Proxy for Cerebral Blood Flow in Degenerative Parkinsonism: Comparison with 15O-H2O PET/CT.
Objective: To evaluate the relationship between R1 from 18PR04.MZ and CBF assessed by 15O-H2O PET/CT in patients with parkinsonian syndromes. Background: 18PR04.MZ is an effective…The Impact of Dopamine-Induced Impulse Control Disorders on Quality of Life in Young-Onset Parkinson’s Disease
Objective: To quantify how impulse control disorders (ICDs) alter day-to-day functionality and overall quality of life (QoL) among individuals living with Young-Onset Parkinson’s Disease (YOPD),…Complete Resolution of Troublesome Dyskinesia in People With Advanced Parkinson’s Disease Treated With Foslevodopa/Foscarbidopa: Post Hoc Analysis From a 52-Week Phase 3 Trial
Objective: To evaluate the achievement of complete elimination of troublesome dyskinesia (TSD) and associated changes in Off time, motor aspects of experiences of daily living…
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