Clinical, Neurophysiological, and Biological Insights into Levodopa-Induced Dyskinesias
Objective: The aim of this study was to determine the clinical, neurophysiological and biological features of Parkinson's Disease (PD) patients with L-Dopa-induced dyskinesias (LIDs). Background:…Correlation Between Mild Cognitive Impairment and Levodopa Induced Dyskinesia in Parkinson’s Disease Patients
Objective: The aim of this study is to compare the level of mild cognitive impairment in Parkinson’s disease patients with and without levodopa-induced dyskinesia. Additionally,…Clinical benefit of Opicapone in patients with different Parkinson disease phenopytes. The OPTIMO study
Objective: To assess the clinical benefit induced by opicapone (OPC) as an add-on therapy to levodopa in fluctuating Parkinson’s disease (PD) patients with special focus…Abnormal Subthalamic Oscillations as Potential Biomarkers for Identifying the Dyskinesia-Inducing Region within the Subthalamic Nucleus in Parkinson’s Disease
Objective: To investigate the characteristics of local field potentials (LFPs) associated with the STN region that elicit stimulation-induced dyskinesia (SID) in PD patients. Background: Approximately 50%…Prevalence of Helicobacter Pylori Infection Among Nepalese Parkinson’s Disease Patients and their Clinical Manifestations
Objective: To know the prevalence of Helicobacter Pylori infection among Nepalese Parkinson´s Disease patients and understand their clinical characteristics Background: Helicobacter pylori (HP) is prevalent…Efficacy and Safety of Amantadine in Parkinson’s Disease with Dyskinesia and Motor Fluctuations: A Systematic Review and Meta-Analysis
Objective: To evaluate the efficacy and safety of oral amantadine (AMA) compared to placebo in the treatment of dyskinesia (DYS) and motor fluctuations (MF) in…Altered EEG Theta Activity Characterizes Parkinson’s disease with Levodopa-induced Dyskinesia
Objective: We explored the relationship between the build-up and the downscaling process in patients with Parkinson’s disease by analyzing theta frequency spectral bands. Background: During…Delta(0.5-2Hz) Spectral Power reduction in the frontal region in NREM Sleep are Associated with dyskinesia in Parkinson’s Disease
Objective: Our study aimed to establish the objective physiological indicators assessed by polysomnography(PSG) that are associated with dyskinesia in PD patients.Our study aimed to establish…Motor complications in Parkinson’s disease
Objective: To determine the presence, severity, functional impact and predisposing factors of motor complications. Background: Motor complications are well recognized in Parkinson’s disease (PD), but…NLX-112 has favorable safety and tolerability and displays efficacy against levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD)
Objective: To assess the safety, tolerability and preliminary efficacy of NLX-112 (a.k.a. befiradol) in patients with moderate to severe LID in PD: a randomized, double-blind,…
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