Reduced Cholinergic Activity and Electrophysiological Slowing in Patients with GBA-PD
Objective: To explore neurophysiological changes using quantitative EEG (qEEG) and transcranial magnetic stimulation (TMS) in PD patients carriers and non-carriers of GBA1 mutations. Background: qEEG…Dynamic Neural States underlying Freezing of Gait in Parkinson’s Disease
Objective: This study aimed to characterize dynamic brain states during freezing of gait in Parkinson’s disease using Hidden Markov Modelling of EEG data. Background: Freezing…Pain Inverts the Relationship Between Beta-band Power and Fatigue Severity in PD: an EEG Study
Objective: This study aims to compare EEG band power and its relationship to fatigue severity in PD patients with and without chronic pain. Background: Fatigue…Cortical Disinhibition and Beta Hypersynchrony underlying Freezing of Gait in Parkinson’s Disease: a TMS–EEG Study
Objective: To investigate whole-cortex functional alterations in Parkinson’s disease patients with freezing of gait (PD-FOG) using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG). Background: Our…Characteristics of Cortical Beta Bursts in Parkinson’s disease
Objective: 1. Do patients with PD experience changes in cortical beta bursts in both the low and high β frequency bands?2. Are bursts of different…Acute administration of methylphenidate modulates functional connectivity during the processing of irrelevant stimuli in Parkinson’s disease patients
Objective: Examine the effects of a single dose of methylphenidate (MPD), on event-related functional connectivity (FC), in patients with Parkinson’s disease (PD). Background: Recent studies…Non-Rapid Eye Movement Sleep Neurophysiological Alterations in Lewy Body Disorders
Objective: To characterise NREM sleep neurophysiology across multiple domains in Lewy body disorders (LBDs) relative to healthy controls. Background: Sleep disturbances are highly prevalent in…Sleep Slow-Wave Activity Topography and Dynamics in PD: Relationships with Resting-State fMRI data and Glymphatic Clearance
Objective: We propose that abnormal EEG power dynamics during sleep are associated not only glymphatic dysfunction but also signal fundamental changes in resting-state functional connectivity…Electroencephalographic and Functional Magnetic Resonance Imaging Analysis of Daytime Sleepiness in Parkinson’s Disease
Objective: To explore the electroencephalographic (EEG) characteristics and brain functional connectivity patterns in Parkinson's disease (PD) patients with daytime sleepiness. Background: Daytime sleepiness is a…Developing non-invasive EEG biomarkers for Parkinson’s disease using concurrent subthalamic nucleus/cortical recording as ground truth.
Objective: In the present study, we aimed to: (1) isolate the motor cortical EEG activity responsible for translating subthalamic nucleus (STN) beta hypersynchrony into bradykinesia;…
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