Framework for Future Neurology Trials: Enhanced Scientific Rigor Through Innovative Decentralized Trial Methodology
Objective: To characterize feasibility and scientific rigor of a decentralized (DCT) Phase 3 trial in essential tremor (ET), emphasizing diagnostic standardization, real-world population access, centralized…Tablet-Based Quantitative Evaluation of Finger Movement in Essential Tremor: A Visual-Motor Task Study
Objective: Extending our prior FMAS validation in Parkinson’s disease (PD), we utilized this tablet-based system to quantify finger movement profiles in Essential tremor (ET) patients…Anti Tremorgenic Properties Of Eslicarbazepine Acetate in The Harmaline Induced Tremor Mouse Model
Objective: This study evaluated potential anti-tremor properties of eslicarbazepine acetate (ESL), an antiseizure medication approved for treatment of focal-onset epilepsy, in the harmaline-induced tremor mouse…Genetic analysis of the SLC38A6 gene in Chinese patients with essential tremor
Objective: To evaluate the contribution of rare SLC38A6 variants to essential tremor (ET) susceptibility in an independent Chinese cohort through gene-level burden analysis and family…Setting research priorities for Essential Tremor: a James Lind Alliance Priority Setting Partnership
Objective: To identify and rank the top research priorities for people with Essential Tremor (ET), their carers and healthcare professionals using the James Lind Alliance…Ulixacaltamide Demonstrates Broad Functional Improvement Across Individual Domains of Activities of Daily Living in Essential Tremor
Objective: To assess the breadth of functional improvement in adults with essential tremor (ET) treated with ulixacaltamide in the Phase 3 Essential3 program. Background: ET…Safety and Efficacy of a Wrist-Worn Vibratory Stimulator for Upper Limb Tremor Reduction in Essential Tremor (ULTRE): A Randomized, Controlled Trial
Objective: To assess the safety, tolerability, and efficacy of a wrist-worn vibratory stimulator by comparing two active paradigms (Pulsed (AP), Continuous (AC)) to Sham in…Are we there yet? A Comprehensive Assessment of the Challenges in Standardizing MRgFUS Outcomes in Essential Tremor
Objective: To evaluate heterogeneity of outcomes following magnetic resonance-guided focused ultrasound (MRgFUS) for essential tremor (ET), highlighting differences in assessment time points, thresholds and definitions.…Efficacy of Ventral Intermediate Nucleus Deep Brain Stimulation for Head Tremors in Essential Tremor: A Single-Center Retrospective Analysis
Objective: To evaluate the efficacy of ventral intermediate nucleus (VIM) deep brain stimulation (DBS) in treating head tremors in patients with essential tremor (ET) and…Spatiotemporal Neural Dynamics of the Cerebellum Underlie Differential Therapeutic Outcomes in Essential Tremor Subtypes
Objective: Identify differential therapeutic responses in essential tremor (ET) models.Characterize the spatiotemporal neural dynamics and circuitry features in these models.Elucidate neuronal mechanisms underlying drug-response dynamics…
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