Axon terminal hypertrophy of striatal projection neurons with levodopa-induced dyskinesia priming
Objective: We examined whether levodopa-induced dyskinesia (LID) and axon terminal hypertrophy gradually develop with repeated levodopa treatment in Parkinsonian rats to prove that the hypertrophy…KINETIC 2: An ongoing phase 2b, randomized, dose-response study of SAGE-324/BIIB124 for the treatment of essential tremor
Objective: KINETIC 2 (NCT05173012) is an ongoing, phase 2b, randomized, double-blind, placebo-controlled, dose-response study that aims to evaluate the efficacy, safety, and tolerability of SAGE-324/BIIB124…Cerebral Topography of [11C]-Flumazenil GABAA Receptor Expression in Parkinson’s Disease Fallers and Freezers
Objective: To examine the cerebral topography of GABAA Receptor Expression in Parkinson’s Disease (PD) Fallers and Freezers. Background: Episodic mobility disturbances, like falls and freezing…Electrophysiological correlates of neurological deficits in toxic-metabolic encephalopathy
Objective: We used transcranial magnetic stimulation (TMS) paradigms reflecting GABAA, GABAB, cholinergic and glutamatergic transmission at the motor cortex level, to investigate pathophysiology of different…A phase 2b, randomized, dose-response study of SAGE-324/BIIB124 for the treatment of essential tremor: KINETIC 2 trial in progress
Objective: The phase 2b KINETIC 2 trial is a double-blind, randomized, placebo-controlled, dose-response study designed to evaluate SAGE-324/BIIB124 (SAGE-324) for the treatment of patients with…Changes in GABAergic transmission of striatal neurons in presymptomatic Huntington’s Disease
Objective: To determine whether parameters of synaptic and extrasynaptic GABAergic inhibition of striatal projection neurons are altered in presymptomatic BACHD mice. Background: One attractive early…GABA-A Receptor Positive Allosteric Modulators: Phase 2 Proof of Concept Studies of Brexanolone Injection and SAGE-217 in Essential Tremor
Objective: To examine use of γ-aminobutyric acid (GABA) type A receptor (GABA-A-R) positive allosteric modulators (PAMs) in the treatment of essential tremor (ET) in early…Activity of Neurosteroid GABAA Positive Allosteric Modulators in Preclinical Harmaline Model for Essential Tremor
Objective: The objective of the present study was to test the activity of neurosteroid (NAS) GABAA positive allosteric modulators, including novel synthetic NAS SGE-516, at…A Case of Pregabalin induced Parkinsonism
Objective: Present a case of parkinsonism after administration of pregabalin, a rare case Background: Drug induced parkinsonism is the second common movement disorders after Parkinson’s…Ocular motor function in stiff person syndrome – Role of GABA and beyond
Objective: Delineate pathophysiology of gaze-holding function in stiff person syndrome (SPS). Background: Glutamic acid decarboxylase (GAD) catalyzes conversion of glutamate to gamma-aminobutyric acid (GABA). Anti-GAD…