Intrathecal baclofen (ITB) therapy in the treatment of severe spasticity: Safety and Product Performance from a Large Multinational Multi-Center Registry
Objective: •To use real-world registry data to augment available safety data, product performance and support overall efficacy. •To utilize registry data to broaden awareness of…Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats
Objective: (1) Curcumin is well tolerated curcuminoid used as supplement for various disorders but problem is its low oral bioavailability. (2) Piperine is combined to…Therapeutic potential of compounds preferring specific GABAA receptor subunits for the treatment of dystonia?
Objective: To further define the pathophysiology of the reduction of striatal interneurons in an animal model of dystonia and to develop novel therapeutic strategies targeting…Does repetitive transcranial magnetic stimulation (rTMS) affect cognitive function in Parkinson’s disease by modulating high-frequency brain oscillations: A magnetoencephalography (MEG) study
Objective: To better understand the mechanisms of how repetitive transcranial magnetic stimulation (rTMS) may improve cognitive function in Parkinson's disease (PD). Background: Cognitive dysfunction and…Dopaminergic medication affects choice bias in Parkinson’s disease
Objective: Assess dopaminergic effects on choice bias in Parkinson's disease (PD). Background: Bradykinesia, rigidity and resting tremor are the core symptoms of PD, but many…Cerebellar GABA-A receptor activity is inversely correlated with gait speed in Parkinson’s disease
Objective: To investigate the relationship between regional cerebral expression of benzodiazepine receptors and gait speed in Parkinson's disease (PD). Background: Flumazenil is a short-acting intravenously…Motor cortex neuroplasticity and learning following high-intensity interval exercise
Objective: To determine the effect of high-intensity interval (HIT) exercise on motor cortex plasticity and learning in healthy young adults. Background: Motor skill learning requires…Cerebellar GABA in essential tremor and dystonic tremor: A MR spectroscopy study
Objective: To explore the role of GABA in the pathophysiology of ET and DT by using MR spectroscopy. Background: The mechanisms of tremor in ET…Dysregulations of GABAergic neurotransmission in Huntington’s disease brain
Objective: To investigate (1) the expression of GABAA receptors and KCC2 in both Huntington's disease (HD) mouse models and patients and (2) the inhibitory effect…Neuroprotective potential of L-theanine against excitotoxic neuronal death induced by quinolinic acid: Possible neurotransmitters and nitric oxide modulation mechanism
Objective: To evaluate the neuroprotective efficacy of L-theanine, an unique amino acid with neuroprotective properties, for its beneficial potential if any, in quinolinic acid induced…