The N6-Methyladenosine mRNA Methylase METTL14 Regulates TLR4-mediated intestinal dysfunction in Parkinson’s Disease
Objective: The aim of this study is to explore the function and mechanism of RNA m6A modification in gut-derived inflammation of Parkinson's disease (PD). Background:…LRRK2 G2019S as a trigger of inflammatory signaling in patient-derived microglia
Objective: This study explores the inflammatory processes in leucine-rich repeat kinase 2 (LRRK2)- microglia carrying the G2019S mutation and determines their contribution to Parkinson’s disease…Protective effect and mechanism of TREM2 in Parkinson’s disease with cognitive impairment
Objective: this study explored whether TREM2 plays a protective role in PD with cognitive impairment by promoting the activation of DAM. Background: The latest research…Plasma biomarkers in iRBD patients serve as potential markers of early PD and motor severity
Objective: We aimed to investigate biomarkers of inflammation and neuroaxonal damage in people with isolated REM sleep behaviour disorder (iRBD) compared to controls, and understand…Therapeutic potential of luteolin in manganese induced Parkinson’s disease: Targeting neuroinflammation and oxidative stress.
Objective: To investigate the neurodegenerative facets of Manganese (Mn) in rat model in rat model of Parkinson's disease.To study the neuroprotective effect of luteolin in…Molecular alterations and pathological remodeling of colonic wall in patients with Parkinson’s disease
Objective: To evaluate, in an integrated manner, changes in faecal microbiota composition, morpho-functional alterations of the colonic mucosal barrier and changes of inflammatory markers in…Aerobic glycolysis regulates microglia-mediated neuroinflammation by promoting H3K9 lactylation in Parkinson’s disease
Objective: This study aims to investigate the role of histone lactylation in microglia-mediated neuroinflammation and dopaminergic (DA) neuronal damage in Parkinson’s disease (PD). Background: Augmented glycolysis induced by metabolic…Single-cell characterization of patient midbrain tissue reveals tissue remodeling and glial activation in Parkinson’s disease
Objective: We aim to characterize the contribution of each midbrain cell type to PD pathology, and to identify cell types associated with genetic PD-risk variants.…Alteration of peripheral blood cell profiles in Parkinson’s disease: a retrospective case-control study
Objective: The aim of this study is to investigate the relationship between peripheral blood cell profiles and Parkinson's disease (PD). Background: Abnormal immune response and systemic inflammation have…Impact of Th17 pathway-related immuno-inflammatory cytokines in the risk and severity of Parkinson’s Disease.
Objective: To delineate the impact of T helper 17 (Th17) pathway-related cytokines in the risk, severity and psychopathology of patients with Parkinson’s Disease (PD). Background:…
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