Astrocyte Derived Extracellular Vesicle miR 210 Expression in Exenatide Treated Patients with Parkinson’s Disease
Objective: To investigate miR‑210 expression in astrocyte‑derived extracellular vesicles (ADEVs) from individuals with PD treated with Exenatide versus placebo. Background: Hypoxic stress profoundly alters neuronal…Phase 1 Study of BT-409, a potent, selective, brain-penetrant, and oral small molecule inhibitor of NLRP3 in Healthy Volunteers and Adults with Parkinson’s disease
Objective: The objective of the study is to evaluate the safety, tolerability, and pharmacokinetics of BT-409. Background: Chronic activation of innate immune pathways has emerged…Clinical Relevance of Oral Health Assessment in Parkinson’s Disease Monitoring
Objective: To evaluate the clinical relevance of oral health assessment in Parkinson’s disease (PD) by determining whether oral inflammatory, microbial, and periodontal alterations are associated…Stage-Dependent Dysregulation of Peripheral TREM2, SOD1, and Neurofilament Light Chain Across the Parkinson’s Disease Continuum
Objective: To evaluate plasma and PBMC biomarkers of neurodegeneration, neuroinflammation, microglial activation, and oxidative stress across clinically defined stages of Parkinson's disease (PD). Background: PD…Longitudinal Association Between Baseline CSF GFAP Levels and Clinical Progression in Parkinson’s Disease A PPMI Study
Objective: To investigate whether baseline cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) levels predict changes in cognitive performance (MOCA) and motor severity (UPDRS) over…Evidence of Systemic and Neuro-Inflammation in Progressive Supranuclear Palsy: Insight from an Imaging-Inflammation Study
Objective: To investigate the role of Th17 pathway in systemic and central inflammation in PSP and to identify signatures of inflammation-induced neurodegeneration in PSP. Background:…Differential Microglial Activation and p-Ser129 Alpha-Synuclein Induction by Neurotropic and Non-Neurotropic Influenza A Virus Strains
Objective: To compare the innate immune responses and neurodegenerative marker induction in human microglia following infection with neurotropic vs. non-neurotropic Influenza A virus (IAV) under…Molecular Profiling of Brain-Derived Extracellular Vesicles and Fluid Biomarkers in Parkinsonism: Distinct Signatures and Clinical Correlates in Progressive Supranuclear Palsy
Objective: (1) To validate serum-based enrichment of neuronal (L1CAM+) and microglial (TMEM119+) EVs in PSP; (2) to characterize α-synuclein, tau, and inflammatory/autophagic mediators in EVs…Targeting the NLRP3 Inflammasome by PD180970 Based on Differential Susceptibility to MPTP
Objective: To delineate the role of NLRP3 Inflammasome activation to differential vulnerability in PD and to assess the therapeutic efficacy of PD180970 in targeting this…Characterising immune changes in the nose in Parkinson’s disease
Objective: To characterise the profile of innate immune cells in the nasal cavity in people with Parkinson’s disease (PD) versus controls. Background: Neuroinflammation provides novel…
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