The effect of vortioxetine and mirtazapine on levodopa-induced dyskinesia in a rat model of Parkinson’s disease
Objective: To investigate the effect of vortioxetine and mirtazapine on levodopa-induced dyskinesia (LID) in a rat model of Parkinson’s disease (PD), we analyzed abnormal involuntary movements (AIMs)…Long-Term Effect of Opicapone in Parkinson’s Patients Without Motor Complications: 1.5-year EPSILON Study Findings
Objective: We report motor function, motor complication and tolerability findings of the EPSILON study up to 1.5 years. Background: The 24-week, double-blind, placebo-controlled Phase III…The Impact of Levodopa on Gait in Parkinson’s Disease: A Quantitative Analysis of Striatal Dopamine Transporter Availability and Lateralization
Objective: This study aimed to analyze gait changes in Parkinson’s disease (PD) patients before and after levodopa administration, examining correlations between gait parameters and striatal…Assessing the potential association of rs2298383 in ADORA2A as a predictor of Levodopa-Induced Dyskinesia in Latin American Parkinson’s Disease patients
Objective: To analyze the association between ADORA2A-rs2298383 and levodopa induced dyskinesias (LID) in a cohort of Latin American Parkinson’s disease patients. Background: Previous evidence has…Computer Vision Quantification of Repeated Finger Tapping Demonstrates Aberrant Plasticity in Parkinson’s Disease
Objective: Test if symptoms of Parkinson's disease (PD) develop through aberrant plasticity. Background: Recent results in 6-hydroxydopamine-lesioned mice show that repeated performance of simple motor…Mucuna pruriens for FOG in Parkinson’s disease, Do we have a solution for this trivial problem?
Objective: To study the effects of Mucuna Pruriens when administered via inhalation route, to alleviated symptoms of Parkinson's disease most importantly freezing of gait. Background: Mucuna…Mutations of the VPS13A gene in a patient with Early-Onset Parkinson’s Disease: A case report.
Objective: To describe the case of a patient with early-onset Parkinson's Disease (PD) with variants of the VPS13A gene. Background: The vacuolar protein sorting 13A…L-DOPA Induced Iron Accumulation in the Ventral Midbrain: The Roles of Sex and Iron Repletion
Objective: This study aims to investigate the impact of L-3,4-dihydroxyphenylalanine (L-DOPA) on ventral midbrain (VMB) iron levels under iron deficiency (ID) and repletion (IR) conditions…Unraveling the Intertwined Relationship of DBS, Parkinson’s Disease Subtype and LEDD: A Retrospective Study
Objective: To assess the impact of deep brain stimulation (DBS) target and Parkinson’s disease (PD) motor subtype on the total levodopa equivalent daily dose (LEDD)…VPS13C: a Modifier Gene causing Suboptimal Response to Levodopa in Early-Onset Parkinson’s Disease
Objective: To describe a retrospective clinical study of four cases carrying heterozygous pathogenic variants in the VPS13C gene with a clinical diagnosis of Early-Onset Parkinson’s…
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