Acute L-dopa Challenge Test In Early Parkinsonism With Respect To Presence Of Red Flag Signs &MRIAbnormalitis
Objective: In this study we have tried to find any association between acute levodopa challenge responsiveness,red flag signs of parkinsonism and neuroimaging abnormality Background: Distinguishing…Mechanisms of sub-anesthetic ketamine infusions to reduce L-DOPA-induced dyskinesia: effects on striatal mTOR signaling and beta band oscillations in striatum and motor cortex
Objective: To evaluate mechanism of long-term activity of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesia (LID). Background: We have published preclinical evidence and patient case…Baseline characteristics of the population enrolled to a randomized clinical study of subcutaneous levodopa/carbidopa (ND0612) infusion in patients with advanced PD
Objective: To evaluate whether continuous 24 hours delivery of subcutaneous ND0612 offers practical and clinical benefits over continuous delivery over the waking day (14 hours).…Levodopa induced dyskinesia in a case of progressive supranuclear palsy.
Objective: We describe the mechanism of dyskinesia in patients with progressive supranuclear palsy (PSP). Background: Levodopa generally shows a poor effect to parkinsonism in patients…Does levodopa-carbidopa intestinal gel in Parkinson’s disease patients increase the risk on polyneuropathy?
Objective: To analyze the influence of the overall levodopa exposure on the risk of polyneuropathy (PN) in levodopa-carbidopa intestinal gel (LCIG)-infusion treated patients with Parkinson’s…Patient perspectives of using the ND0612 mini-pump
Objective: To evaluate patient and caregiver usability and satisfaction with the mini-pump that will be used for continuous ND0612 delivery among patients with moderate-severe PD.…Impact of levodopa-induced dyskinesias on Health-related Quality of Life. Results from the French COPARK study.
Objective: To assess the impact of LIDs on HRQoL in this large sample of unselected Parkinson’s Disease (PD) patients and to assess the factors related…Decision making under uncertainty in medicated and un-medicated Parkinson’s disesase
Objective: To evaluate decision making under risk in Parkinson’s disease patients, both medicated and un-medicated states probing constituent cognitive operations driving choice. Background: Prior literature…ND0612 (levodopa/carbidopa for subcutaneous infusion) achieves stable levodopa plasma levels when administered in low and high doses in patients with PD
Objective: Characterize the levodopa pharmacokinetic profile derived from continuous subcutaneous (SC) administration of ND0612. Background: Continuous levodopa/carbidopa (LD/CD) infusion is considered the optimal delivery route…Factors determining the motor outcome of STN DBS in PD patients: Evidence for Dual Actions
Objective: We investigated factors determining the motor outcome of STN DBS in patients with Parkinson disease (PD). Background: The STN DBS has revolutionized the management…
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