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Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Lewy bodies"

  • 2025 International Congress

    Amygdala-predominant Lewy Body Disease is a Lens for Understanding Pathogenesis and the Alpha-synuclein Seeding Assay in Human Postmortem Brain

    D. Fischer, L. Vandevrede, W. Seeley, S. Spina, S. Li, W. Lee, T. Lamore, F. Wekselman, A. Lario Lago, L. Grinberg (San Francisco, USA)

    Objective: To map alpha-synuclein (asyn) and tau markers in amygdala-predominant Lewy body disease (AP-LBD), identifying spread pathways and vulnerable cell populations. Background: LBD often co-occurs…
  • 2025 International Congress

    GBA1 deficiency promotes the spread of Lewy pathology

    S. Fish, A. Park, J. Weiss, M. Kim, E. Chiu, M. Callier, S. Yu, M. Davis (Seattle, USA)

    Objective: To elucidate how GBA1 deficiency promotes the spread of Lewy pathology from cell to cell. Background: Mutations in the gene glucosidase, beta acid 1 (GBA1) not…
  • 2025 International Congress

    Spatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies

    S. Rumpf, F. Strübing, K. Nalbach, S. Lichtenthaler, C. Vargiu, P. Parchi, G. Höglinger, J. Herms, T. Koeglsperger (Munich, Germany)

    Objective: To investigate the significance of Lewy body pathology (LBP) in relation to midbrain molecular and cellular changes associated with Parkinson's disease (PD). Background: The…
  • 2025 International Congress

    Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing

    L. Novakova, M. Gajdos, D. Carbol, I. Rektorova (Brno, Czech Republic)

    Objective: Aim of this study is to describe specific alterations in comprehending syntactically complex sentences in patients with Lewy body diseases (LBDs) that already have…
  • 2025 International Congress

    Identifying Cut-off Values, Effects of AD Co-pathology, Sex Differences, and Temporal Changes of 123I-FP-CIT SPECT in Autopsy-proven LBD

    T. Miyagawa, S. Przybelski, C. Cynthia, HK. Minmin, L. Forsberg, J. Fields, S. Mccarter, T. Ferman, V. Ramanan, J. Graff-Radford, D. Jones, R. Savica, D. Knopman, R. Petersen, R. Reichard, A. Nguyen, D. Dickson, M. Murray, G. Day, N. Graff-Radford, C. Lachner, E. St Louis, M. Jain, K. Kantarci, V. Lowe, B. Boeve (ROCHESTER, USA)

    Objective: We analyzed autopsy-proven Lewy body disease (LBD) and/or Alzheimer’s disease (AD) dementia patients with 123I-FP-CIT SPECT to investigate previously unclarified detailed aspects of 123I-FP-CIT…
  • 2025 International Congress

    Seed amplification assay detects alpha-synuclein in cerebrospinal fluid in pre- and symptomatic autosomal dominant Alzheimer’s disease

    A. Ahuja, J. Ringman, K. Wong (Los Angeles, USA)

    Objective: To examine the ability to detect concurrent Lewy Body Disease via Lew Body pathology (LBP) in Autosomal Dominant Alzheimer’s Disease (ADAD) through detection of…
  • 2024 International Congress

    Sex Differences for Regional Lewy Body Pathology in Pathologically-Defined Lewy Body Dementia

    E. Bayram, D. Coughlin, S. Koga, I. Litvan, D. Dickson (La Jolla, USA)

    Objective: To investigate sex differences for regional Lewy body (LB) pathology burden, and regional LB pathology association with clinical diagnosis across people with a high…
  • 2024 International Congress

    Cardiovascular Associations of Cortical Lewy Bodies in the Oldest Old: The 90+ study

    R. Rajmohan, Z. Al-Darsani, N. Phielipp, T. Montine, M. Corrada, C. Kawas (Orange, USA)

    Objective: To identify potential risk factors for cortical Lewy Bodies (CLB) in the oldest-old (> 90 years old), we investigated if cardiovascular medical histories, medication…
  • 2024 International Congress

    Assessing the Accuracy of Clinical Diagnostic Criteria of Lewy Body Dementia for Detection of Lewy Body Disease in the Oldest-Old: The 90+ Study

    R. Rajmohan, Z. Al-Darsani, N. Phielipp, T. Montine, M. Corrada, C. Kawas (Orange, USA)

    Objective: To examine if Lewy Body dementia (LBD) clinical diagnostic criteria will be less accurate for detecting Lewy Body Disease (the pathological diagnosis) in the oldest-old…
  • 2024 International Congress

    Accuracy of Clinical features for Substantia Nigra Hypopigmentation and Cortical Lewy Body Presence in the Oldest-Old: The 90+ Study

    R. Rajmohan, Z. Al-Darsani, N. Phielipp, T. Montine, M. Corrada, C. Kawas (Orange, USA)

    Objective: To improve clinical diagnostic accuracy of Lewy Body Dementia (LBD), we assessed if frontal release signs are a useful screening tool for cortical Lewy…
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