MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Lewy bodies"

  • 2023 International Congress

    Assessment of variation in α-synuclein seed amplification assay results in the PPMI cohort: Association with hyposmia

    A. Siderowf, L. Concha-Marambio, D. Lafontant, R. Alcalay, L. Chahine, T. Faroud, D. Galasko, K. Kieburt, K. Merchant, B. Mollenhauer, K. Poston, J. Seibyl, C. Tanner, T. Simuni, D. Weintraub, A. Videnovic, S. Choi, C. Caspell-Garcia, C. Coffey, M. Frasier, L. Oliveira, S. Hutten, T. Sherer, C. Soto, K. Marek (Philadelphia, USA)

    Objective: To understand molecular heterogeneity among Parkinson’s disease (PD) patients, and controls based on α-synuclein seed amplification assay (SAA) results. Background: α-synuclein seed amplification assay…
  • 2023 International Congress

    Health status of Lewy Body Dementia caregivers predicts psychological response to peer mentoring intervention

    M. Suresh, K. Woo, J. Fleisher (Chicago, USA)

    Objective: To understand how caregiver health status influences response to a peer mentoring intervention in caregivers of individuals with Lewy Body Dementia (LBD). Background: Caregiving…
  • 2023 International Congress

    Sex differences for clinicopathological correlations in people with Lewy body pathology

    E. Bayram, D. Coughlin, I. Litvan (La Jolla, USA)

    Objective: To determine sex-specific clinical correlations of different Lewy body (LB), Alzheimer’s disease (AD) pathology staging and nigral neuron loss levels in people with LB…
  • 2023 International Congress

    Impact of the severity of Parkinson’s disease on skin elasticity

    SY. You, HJ. Park (Daegu, Republic of Korea)

    Objective: To investigate changes in skin elasticity according to the severity of symptoms of Parkinson's disease. Background: Parkinson's disease (PD) is a neurodegenerative disease caused…
  • 2023 International Congress

    Recruiting people at risk of Parkinson’s disease: comparative data from PPMI Online and HeBA Kassel

    E. Brown, S. Schade, S. Ghosh, K. Rege, V. Satagopam, M. Marti, W. Poewe, R. Kruger, C. Trenkwalder, L. Chahine, R. Dobkin, D. Weintraub, E. Tolosa, C. Marras, E. Bryan, J. Valverde Twiggs, M. Korell, K. Marek, B. Mollenhauer, C. Tanner (San Francisco, USA)

    Objective: To compare a US- and Germany-based staged screening process to identify people at risk of developing Parkinson’s disease (PD). Background: The Parkinson’s Progression Marker…
  • 2022 International Congress

    Blaming neuromelanin for Parkinson’s disease: time-dependent tyrosinase overexpression drives endogenous synucleinopathy in non-human primates

    J. Lanciego, J. Chocarro, A. Fajardo-Serrano, A. Vazquez, AI. Rodriguez-Perez, J. Labandeira-Garcia, M. Vila, A. Rico (Pamplona, Spain)

    Objective: Development and characterization of a novel non-human primate model of Parkinson’s disease based on the AAV-mediated forced expression of human tyrosinase Background: Although neuromelanin…
  • 2022 International Congress

    Smoking and Substantia Nigra Neuron Density in the Presence and Absence of Lewy Pathology

    G. Ross, R. Abbott, H. Petrovitch, J. Duda, J. Uyehara-Lock, K. Masaki, C. Tanner (Honolulu, USA)

    Objective: Our objective is to examine the association of mid-life smoking with post mortem substantia nigra (SN) neuron density in the presence and absence of…
  • 2022 International Congress

    Visual Hallucinations and Parkinson’s Disease Neuropathology among Decedents with and without Parkinson’s Disease or Lewy Body Dementia During Life

    H. Petrovitch, R. Abbott, M. Barrett, K. Masaki, C. Tanner, J. Uyehara-Lock, W. Ross (Honolulu, USA)

    Objective: The purpose of this report is to examine the association between visual hallucinations during life and substantia nigra (SN) neuron density and Lewy pathology…
  • 2022 International Congress

    Addressing pathological alpha-synuclein aggregation using a small molecule strategy

    E. Tsika, N. Ait-Bouziad, N. Dreyfus, C. Vallet, L. Maliqi, L. Aeschbach, S. Pautet, S. Menant, I. Borovko, L. Rey-Bellet, A. Ouared, R. Migliorini, K. Piorkowska, V. Darmency, H. Kroth, S. Poli, A. Pfeifer, M. Kosco-Vilbois (Lausanne, Switzerland)

    Objective: The discovery of cell-permeable, orally bioavailable and brain penetrant small molecules with the potential of inhibiting aggregation and intracellular accumulation of pathological alpha-synuclein (a-syn)…
  • 2022 International Congress

    Incidental Lewy Body disease and idiopathic Parkinson’s disease: from common pathogenic factors to the overlapping clinical features

    E. Sansa, T. Warner, E. Depablo Fernandez (London, United Kingdom)

    Objective: To compare established early symptoms and risk factors associated with Parkinson’s disease (PD) in a cohort of incidental Lewy Body disease (iLBD) and healthy…
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