Modeling of Parkinson’s disease by damaging dopaminergic neurons
Objective: Analysis of the simulation of Parkinson's disease in rats using 6-OHDA.Analysis of the simulation of Parkinson's disease in rats using 6-OHDA. Background: The mechanism…Baicalein incorporated nanoliposome disaggregates alpha-synuclein fibrils
Objective: The aim of this study is to evaluate the depolymerization effect of baicalein on mature fibrils of alpha-synuclein. Background: The aggregation and oligomerization of…A possible case of prodromal DLB with prominent hallucinations, autonomic dysfunction, and REM behavior disorder but absence of cognitive impairment
Objective: Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia, after Alzheimer’s disease (AD). While mild cognitive impairment (MCI) is…A Lewy body disease of widely confirmed Lewy bodies in the cerebral cortexes including the occipital lobe without pathological changes in the hippocampal CA2/3 region
Objective: We present Lewy body disease (LBD) showing unique neuropathological findings which are widely recognized Lewy bodies (LBs) in the cerebral cortexes including the occipital…New Neuropathological Staging System for Lewy Body Disease
Objective: Present the validation of the new proposed novel staging system (NSS) for Lewy body disease and compare it against the previously proposed staging systems. Background:…Comparing motor and neuropathological features of Parkinson’s disease dementia and dementia with Lewy bodies
Objective: To compare motor and neuropathological features of Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) and to determine clinical and neuropathological differences…Prodromal symptoms in clinically diagnosed dementia with Lewy bodies stratified by Lewy body pathology on autopsy
Objective: Compare prodromal neuropsychiatric, sleep, and motor symptoms in patients clinically diagnosed with dementia with Lewy bodies (DLB) with and without Lewy body pathology on…Extracellular α-synuclein enters dopaminergic neurons by modulating flotillin-1-assisted DAT endocytosis
Objective: In this study, we examine the regulatory role of flotillin-1 in dopamine transporter (DAT) trafficking and the impact of extracellular α-synuclein (αS) on this…Structural and functional MRI brain alterations of Lewy body diseases
Objective: We aimed to identify structural and functional brain MRI features of most aggressive phenotypes comparing three clusters of patients with idiopathic and genetic Lewy…Identification and Characterization of Selective and High Affinity Small Molecules as Positron Emission Tomography (PET) Imaging Tracers for Pathological Alpha-Synuclein
Objective: The aim is to develop small molecular weight compounds which bind selectively and with high affinity to alpha-synuclein (a-syn) aggregates as diagnostic PET imaging…
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