Session Information
Date: Monday, September 23, 2019
Session Title: Other
Session Time: 1:45pm-3:15pm
Location: Agora 2 West, Level 2
Objective: Analysis of the simulation of Parkinson’s disease in rats using 6-OHDA.Analysis of the simulation of Parkinson’s disease in rats using 6-OHDA.
Background: The mechanism of neurodegenerative diseases is intracellular aggregation of proteins with pathological conformation, which in turn, initiates a cascade of immune and metabolic disorders in the central nervous system, disrupts mitochondrial function and the energy metabolism of cells, etc. In the study of the pathogenesis of neurodegenerative diseases, the creation of adequate experimental models in animals plays a major role, which is done by damaging dopaminergic neurons.
Method: The simulation was carried out on Wistar rats. Damage to the dopaminergic neurons of the rat brain substance of the brain black substance was performed by introducing 6-OHDA selective neurotoxin into its compact part.
Results: The effect of the introduction of the selective neurotoxin of dopaminergic neurons 6-OHDA into the substantia nigra developed over a period of 3–4 weeks. By the 3rd week of observation in experimental animals during the inspection, there was an increase in rigidity and ptosis of the upper eyelid, a decrease in motor activity and research behavior. It should be noted that the 6-OHDA-model does not reproduce all clinical and pathological features and does not lead to the formation of cytoplasmic inclusions (Lewy bodies) that are pathognomonic for Parkinson’s Disease. However, this model can serve to conduct various behavioral tests and explore the possibilities of correcting the resulting neurological and behavioral disorders.
Conclusion: The benefits explain the widespread use of this model to determine the effectiveness of anti-Parkinsonian compounds, especially those whose action is based on filling the dopamine deficiency. In addition, this experimental model is useful for assessing the effectiveness of neurotransplantation.
To cite this abstract in AMA style:
L. Toshpulatova, M. Kulmanova. Modeling of Parkinson’s disease by damaging dopaminergic neurons [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/modeling-of-parkinsons-disease-by-damaging-dopaminergic-neurons/. Accessed May 21, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/modeling-of-parkinsons-disease-by-damaging-dopaminergic-neurons/