Role of ApoE in α-Synuclein Pathology
Objective: To investigate whether apolipoprotein E (ApoE) isoforms directly interact with α-synuclein and determine how these interactions influence aggregation dynamics and cellular uptake. Background: The…Serum Nutritional Biomarkers Associated with Isolated REM Sleep Behavior Disorder and α-synucleinopathy Phenoconversion
Objective: To investigate the serum nutritional markers in patients with isolated REM sleep behavior disorders (iRBD) and evaluate their associations with the risk of phenoconversion to α-synucleinopathies. Background:…Analysis of Sphingolipid Metabolism Gene Expression in the Parkinson’s Disease Postmortem Brain Dataset
Objective: To investigate the landscape of sphingolipid metabolism gene expression in Parkinson’s disease (PD).To investigate the landscape of sphingolipid metabolism gene expression in Parkinson’s disease…Circadian Regulator REV-ERBα Drives Microglial Lipid Metabolic Reprogramming and Cognitive Impairment in Parkinson‘s Disease
Objective: To investigate the mechanisms by which sleep disturbance exacerbates motor and cognitive deficits in Parkinson’s disease (PD), and to determine how alterations in the…Prosaposin differentially modulates lipid metabolism of striatal and non-striatal dopamine D1 receptor-expressing neurons and regulates L-DOPA-induced dyskinesia
Objective: Chronic treatment of L-DOPA causes dyskinesia (LID) in PD patients. We aim to understand LID from a lipid-metabolism perspective and identify novel therapeutic targets.…Disrupted Lipid Homeostasis and Mitochondrial Remodeling in A53T α-Synuclein Astrocytes
Objective: This study explores lipid metabolic alterations in human astrocytes carrying the A53T α-synuclein mutation and examines their link to mitochondrial organization and cellular bioenergetics.…Contribution of blood lipid profile to long-term outcome in idiopathic normal pressure hydrocephalus
Objective: Here, we outlined the blood lipid profile, including derived indices of metabolic dyshomeostasis, in iNPH patients, and investigated relationships with brain MRI-based pathology markers,…Metabolomic profile as a biomarker of non-motor symptoms severity in patients with Parkinson’s disease
Objective: To investigate possible associations between serum metabolomic profiles and non-motor symptoms (NMS) frequency and intensity in PD patients Background: Metabolomic studies are providing growing…Biofluid Markers in Parkinson’s Patients and Correlation with Cognitive Profile
Objective: The purpose of this study was to determine potential biofluid biomarkers for cognitive impairment in a cohort of Parkinson's disease (PD) patients. Here we…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…
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