The sphingolipid Lyso-Gb3, a biomarker for the lysosomal storage disorder Fabry Disease, is significantly elevated in blood from patients with Parkinson’s Disease
Objective: To better understand lysosomal dysfunction in Parkinson’s Disease. Background: Lysosomal dysfunction and α-synuclein accumulation play central roles in Parkinson’s Disease. They are interconnected by…Lysosomal Lipid Dysregulation in Parkinson’s Disease: Genetic and Medication Effects in CSF Metabolomics
Objective: Define lipid signatures in sporadic, LRRK2, and GBA1 PD and pre-manifest carriers and assess medication impacts. Background: Lysosomal dysfunction contributes to PD, particularly in…The Impact of Anodal transcranial Direct Current Stimulation on the Metabolomic Profiles of Cerebrospinal Fluid in Parkinson’s Disease
Objective: To explore the impact of anodal transcranial direct current stimulation (tDCS) on the cerebrospinal fluid (CSF) metabolomic profile of Parkinson's disease (PD). Background: Transcranial…Platelets Lipidome as Potential Biomarker of Parkinson’s Disease
Objective: The aim of this proejct is to identify novel biomarkers of Parkinson's disease diagnosis and progression, with a focus on GBA-PD. Background: Our previous…Metabolomics Profiling in Egyptian Patients with Alzheimer’s and Parkinson’s Diseases
Objective: To identify differential serum metabolites found in AD and PD patients and their correlations to clinical presentation in Egyptian patients. Background: There is a…Plasma Lipids as Potential Biomarkers for Progression of Sleep Disturbances in Parkinson’s Disease
Objective: Determine if plasma lipid levels can serve as a surrogate biomarker of future onset of RBD symptoms or nighttime sleep burden in patients with…Sex specific role of dyslipidemia and statin use in Parkinson’s disease pathogenesis
Objective: Our aim was to characterize the role of dyslipidemia and statin use in Parkinson’s disease (PD) development, specifically with respect to differences in significance…Fatty Acid Metabolic Reprogramming Regulates Glial-Epithelial Axis via Nur77 Palmitoylation in Intestinal Dysfunction in Parkinson’s Disease
Objective: This study aims to elucidate the regulatory role of stearoyl-CoA desaturase 1 (SCD1) in Parkinson’s disease (PD)-associated intestinal dysfunction, focusing on its mechanism in…Genetic Correlations Between Parkinson’s Disease and Circulating Metabolites
Objective: To use genome-wide association studies (GWASs) to identify genetic correlations between Parkinson’s disease (PD) and circulating metabolites. Background: Metabolomics is the study of small…Rare Variant Analysis of Sphingolipid-related Genes in Large Chinese Parkinson’ s Disease Cohorts
Objective: This study investigated the link between rare variants in sphingolipid-related genes and Parkinson’s disease (PD) in a Chinese mainland population. Background: Recently, growing evidence…
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