Biofluid Markers in Parkinson’s Patients and Correlation with Cognitive Profile
Objective: The purpose of this study was to determine potential biofluid biomarkers for cognitive impairment in a cohort of Parkinson's disease (PD) patients. Here we…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…Parkinsonism Revealing a Late Form of Niemann-Pick Disease About a Case
Objective: Niemann-Pick type B (NPB) is a rare, autosomal dominant hereditary disorder. Clinical presentation is primarily visceral. Neurological manifestations are rare, unlike in other types…Mechanisms of PLA2G6 Deficiency Impacting Mitochondria-associated membranes in Parkinson’s Disease
Objective: This study aims to explore the functions of PLA2G6 protein at the endoplasmic reticulum-mitochondria interface, unveiling the potential mechanisms of PLA2G6-related Parkinson’s disease (PD)…Substantia Nigra Free-Water, Metabolic Markers, and Motor Variability in Older Adults with Diabetes
Objective: To examine whether nigral microstructural integrity measured via substantia nigra free-water MRI (FW-MRI) relates to peripheral metabolic burden and motor variability across the glycemic…Metabolic Syndrome and Disease Severity in Parkinson’s Disease: Association With Clinical Phenotype and Cerebral Small Vessel Disease
Objective: To evaluate the association between Parkinson’s disease (PD) severity (Hoehn & Yahr, H&Y; mild–moderate–severe) and metabolic syndrome (MetS) defined separately by NCEP-ATP III and…Platelet Lipididomic and Alpha-Synuclein as Peripheral Biomarkers of Disease Progression and Risk in GBA1-Associated Parkinson’s Disease
Objective: To evaluate whether integrated platelet lipidomic and α-synuclein signatures can distinguish idiopathic Parkinson’s disease (iPD), GBA1-associated PD (GBA-PD), and GBA1 non-manifesting carriers (GBA-NMC) from…Role of ApoE in α-Synuclein Pathology
Objective: To investigate whether apolipoprotein E (ApoE) isoforms directly interact with α-synuclein and determine how these interactions influence aggregation dynamics and cellular uptake. Background: The…Serum Nutritional Biomarkers Associated with Isolated REM Sleep Behavior Disorder and α-synucleinopathy Phenoconversion
Objective: To investigate the serum nutritional markers in patients with isolated REM sleep behavior disorders (iRBD) and evaluate their associations with the risk of phenoconversion to α-synucleinopathies. Background:…Analysis of Sphingolipid Metabolism Gene Expression in the Parkinson’s Disease Postmortem Brain Dataset
Objective: To investigate the landscape of sphingolipid metabolism gene expression in Parkinson’s disease (PD).To investigate the landscape of sphingolipid metabolism gene expression in Parkinson’s disease…
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