Metabolomics Profiling in Egyptian Patients with Alzheimer’s and Parkinson’s Diseases
Objective: To identify differential serum metabolites found in AD and PD patients and their correlations to clinical presentation in Egyptian patients. Background: There is a…Plasma Lipids as Potential Biomarkers for Progression of Sleep Disturbances in Parkinson’s Disease
Objective: Determine if plasma lipid levels can serve as a surrogate biomarker of future onset of RBD symptoms or nighttime sleep burden in patients with…Sex specific role of dyslipidemia and statin use in Parkinson’s disease pathogenesis
Objective: Our aim was to characterize the role of dyslipidemia and statin use in Parkinson’s disease (PD) development, specifically with respect to differences in significance…Fatty Acid Metabolic Reprogramming Regulates Glial-Epithelial Axis via Nur77 Palmitoylation in Intestinal Dysfunction in Parkinson’s Disease
Objective: This study aims to elucidate the regulatory role of stearoyl-CoA desaturase 1 (SCD1) in Parkinson’s disease (PD)-associated intestinal dysfunction, focusing on its mechanism in…Genetic Correlations Between Parkinson’s Disease and Circulating Metabolites
Objective: To use genome-wide association studies (GWASs) to identify genetic correlations between Parkinson’s disease (PD) and circulating metabolites. Background: Metabolomics is the study of small…Rare Variant Analysis of Sphingolipid-related Genes in Large Chinese Parkinson’ s Disease Cohorts
Objective: This study investigated the link between rare variants in sphingolipid-related genes and Parkinson’s disease (PD) in a Chinese mainland population. Background: Recently, growing evidence…Association of high-density lipoprotein cholesterol and related inflammatory index with neurodegeneration in drug-naïve dementia with Lewy bodies
Objective: We aimed to clarify the association of serum cholesterol levels and related inflammatory index with the degeneration of nigrostriatal dopaminergic neurons and clinical symptoms…Oligodendrocyte-specific mRNA therapy with lipid nanoparticles
Objective: To develop lipid nanoparticles with high efficiency and specificity to introduce mRNA into oligodendrocytes. To denmonstrate the potential therapy of Krabbe disease as one…Using Zebrafish Model to Investigate Complex Hereditary Spastic Paraplegia Caused by EPT1 Variants
Objective: To generate disease-representative zebrafish models using CRISPR-Cas9 technique.To characterise the zebrafish models by performing phenotypic characterization, neurobiological experiments, lipidomic and RNASeq studies.To test targeted…Efficacy of adhering to a Ketogenic Diet in Parkinson’s Disease: a Systematic Review and Meta-Analysis
Objective: We aimed to analyse the efficacy of Ketogenic Diet (KD) in metabolic and motor characteristics of patients with Parkinson's Disease (PD). Background: Many studies…
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