The potential role of monocytes a-synuclein and lipids as predictors of PD.
Objective: To study the role monocytic A-syn and lipids as biomarkers of PD. Background: A chronic pro-inflammatory pattern is present in Parkinson’s disease (PD) patients’…Effects of Sample Collection Methods on Skin Sebum Volatilome Composition in Parkinson’s Disease Patients – a Methodological Pilot Study
Objective: To assess replicability of skin sebum volatile organic compound (VOC) composition 1) within the same subjects; 2) in frozen vs fresh samples, and 3)…Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies
Objective: We examined the association between environmental phthalates (PAEs) exposure and gut microbiota and metabolome in dementia with Lewy bodies (DLB). Background: Alongside genetic factors,…Interim Analysis of the Feasibility of Mediterranean-Ketogenic Dietary Interventions in Parkinson’s Disease
Objective: To assess the feasibility of combining Mediterranean and ketogenic dietary principles in persons with Parkinson’s disease (PwP). Background: Dietary interventions have been proposed as…Inter- and intra-day variability in β-Glucocerebrosidase activity and pathway biomarkers in healthy volunteers and patients with Parkinson’s disease with a GBA1 mutation
Objective: Characterize inter- and intra-day variability of β-glucocerebrosidase (GCase) activity, using a live-cell assay, and glucosyl-β sphingosine levels in healthy volunteers (HVs) and Parkinson’s disease…AAV-mediated gene therapy for GBA-PD
Objective: Development of a gene therapy-based drug for treatment of GBA-PD, a genetic subtype of Parkinson’s disease Background: Mutations in GBA1, the gene encoding glucocerebrosidase…Long term evaluation of gluten-free diet in Parkinson´s disease patients
Objective: The primary aim of the project was to evaluate the effect of long-term administered gluten-free diet (GFD) on motor symptoms of Parkinson's disease (PD).…Interaction of GCase and ganglioside GM1 in the aggregation of α-Synuclein
Objective: The objective of this work is to investigate the relationship between ganglioside GM1 levels and α-synuclein aggregation in the context of GBA1 mutations. Background:…The functional and lipidome signature of GBA1 mutant dopaminergic neurons
Objective: The work presented here aims to link the lipidome changes leading to functional defects, and eventual cell death, in GBA1 mutant dopaminergic neurons derived…Baseline lipid traits and the clinical characteristics and disease progression in Huntington’s disease
Objective: To clarify the relationship between the baseline serum lipid traits and the clinical characteristics and disease progression in a well-established cohort of Chinese HD…
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