MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Lipid metabolism"

  • 2024 International Congress

    The potential role of monocytes a-synuclein and lipids as predictors of PD.

    S. Lucas-Del-Pozo, G. Uras, D. Moreno-Martinez, F. Fierli, S. Koletsi, C. Manis, P. Caboni, D. Hughes, A. Schapira (London, United Kingdom)

    Objective: To study the role monocytic A-syn and lipids as biomarkers of PD. Background: A chronic pro-inflammatory pattern is present in Parkinson’s disease (PD) patients’…
  • 2024 International Congress

    Effects of Sample Collection Methods on Skin Sebum Volatilome Composition in Parkinson’s Disease Patients – a Methodological Pilot Study

    V. van Midden, L. Strojnik, M. Mencin, N. Ogrinc, M. Kojović (Ljubljana, Slovenia)

    Objective: ​​​​​​To assess replicability of skin sebum volatile organic compound (VOC) composition 1) within the same subjects; 2) in frozen vs fresh samples, and 3)…
  • 2024 International Congress

    Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies

    J. Zou, Z. Deng, L. Li, J. Jing, X. Luo, F. Yu, W. Zeng, W. Bi (Guangzhou, China)

    Objective: We examined the association between environmental phthalates (PAEs) exposure and gut microbiota and metabolome in dementia with Lewy bodies (DLB). Background: Alongside genetic factors,…
  • 2024 International Congress

    Interim Analysis of the Feasibility of Mediterranean-Ketogenic Dietary Interventions in Parkinson’s Disease

    K. Tosefsky, Y. Wang, A. Kuan, V. Ngo, C. Agu, D. Liang, L. Liu, O. Geiger, S. Keymanesh, M. Sacheli, E. Gerson, S. Cresswell (Vancouver, Canada)

    Objective: ​​​To assess the feasibility of combining Mediterranean and ketogenic dietary principles in persons with Parkinson’s disease (PwP). Background: Dietary interventions have been proposed as…
  • 2024 International Congress

    Inter- and intra-day variability in β-Glucocerebrosidase activity and pathway biomarkers in healthy volunteers and patients with Parkinson’s disease with a GBA1 mutation

    J. Vandervalk, D. Dumas, E. Thijssen, D. Pereira, W. Grievink, Y. Yavuz, C. Pesch, D. Ysselstein, M. Hagey, J. Cedarbaum, K. Hunt, P. Kremer (Leiden, Netherlands)

    Objective: Characterize inter- and intra-day variability of β-glucocerebrosidase (GCase) activity, using a live-cell assay, and glucosyl-β sphingosine levels in healthy volunteers (HVs) and Parkinson’s disease…
  • 2024 International Congress

    AAV-mediated gene therapy for GBA-PD

    S. Ayloo, J. Ryu, S. Chou, C. Miller, L. Blatnik, E. Wischhof, J. Bu, W. Mccarty, L. Guo, S. Nass, C. O'Riordan, B. Elmer, C. Mueller, S. Ramachandran (Waltham, USA)

    Objective: Development of a gene therapy-based drug for treatment of GBA-PD, a genetic subtype of Parkinson’s disease Background: Mutations in GBA1, the gene encoding glucocerebrosidase…
  • 2024 International Congress

    Long term evaluation of gluten-free diet in Parkinson´s disease patients

    H. Brožová, K. Poláková, T. Gentileová, M. Fialová, M. Kubjatková, J. Rusz, M. Sap, M. Kuzma, H. Pelantová, M. Jandová, D. Funda (Prague, Czech Republic)

    Objective: The primary aim of the project was to evaluate the effect of long-term administered gluten-free diet (GFD) on motor symptoms of Parkinson's disease (PD).…
  • 2024 International Congress

    Interaction of GCase and ganglioside GM1 in the aggregation of α-Synuclein

    F. Fierli, G. Uras, S. Lucas-Del Pozo, S. Koletsi, V. Lentini, M. Toffoli, P. Caboni, A. Schapira (London, United Kingdom)

    Objective: The objective of this work is to investigate the relationship between ganglioside GM1 levels and α-synuclein aggregation in the context of GBA1 mutations. Background:…
  • 2024 International Congress

    The functional and lipidome signature of GBA1 mutant dopaminergic neurons

    G. Uras, S. Lucas-Del-Pozo, F. Fierli, S. Koletsi, V. Lentini, P. Caboni, C. Manis, D. Di Lisa, A. Andolfi, L. Pastorino, A. Schapira (London, United Kingdom)

    Objective: The work presented here aims to link the lipidome changes leading to functional defects, and eventual cell death, in GBA1 mutant dopaminergic neurons derived…
  • 2024 International Congress

    Baseline lipid traits and the clinical characteristics and disease progression in Huntington’s disease

    SR. Zhang, YF. Cheng, HF. Shang (Chengdu, China)

    Objective: To clarify the relationship between the baseline serum lipid traits and the clinical characteristics and disease progression in a well-established cohort of Chinese HD…
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