Development of novel treatment strategies for SGCE dystonia using patient-derived induced pluripotent stem cells (iPSCs)
Objective: What are the underlying pathological mechanisms of myoclonus dystonia (DYT-SGCE)? Background: Myoclonus dystonia (DYT-SGCE, DYT11) is a combined dystonia characterized by alcohol-sensitive myoclonic-like appearance…Bioengineered nigrostriatal constructs model Lewy pathology
Objective: To better understand Parkinson’s disease (PD) pathophysiology and enhance therapeutic development by bioengineering an in vitro nigrostriatal system that mimics the complex architecture of…Safinamide ameliorates motor deficits and plastic alterations before the onset of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease
Objective: To investigate the effects of safinamide (saf) on synaptic plasticity of spiny projection neurons (SPNs) and the antiparkinsonian effect in dopamine (DA) denervated rats…Safinamide reduces membrane excitability and synaptic transmission of striatal spiny projection neurons in a rat model of Parkinson’s disease
Objective: The effect of safinamide (saf) on the electrical membrane properties and both excitatory and inhibitory synaptic transmission of striatal spiny projection neurons (SPNs) was…Assessment of neuronal morphology to determine the differential susceptibility to Parkinson’s disease using MPTP in two genetically distinct mice strains
Objective: To delineate the contribution of neuronal-dendritic structure in the substantia nigra and striatum, in conferring differential susceptibility to Parkinson’s disease, using two genetically distinct…RNA binding protein mediated regulation of striatal transcriptome in Parkinson’s disease.
Objective: To investigate the role of RNA binding protein Elavl in Parkinson’s disease related adaptive changes in the striatal transcriptome. Background: Elav-like (Elavl or Hu)…Changes in GABAergic transmission of striatal neurons in presymptomatic Huntington’s Disease
Objective: To determine whether parameters of synaptic and extrasynaptic GABAergic inhibition of striatal projection neurons are altered in presymptomatic BACHD mice. Background: One attractive early…Dissecting the molecular mechanisms of Fyn-mediated levodopa induced dyskinesias
Objective: To investigate the crosstalk between D1 receptor (D1R) and the signaling of Fyn protein kinase in a mice model of levodopa (L-DOPA) induced dyskinesias…Striatal PDE10 expression in Parkinson’s disease (PD) and healthy controls using [18F]MNI-659 PET imaging
Objective: To evaluate the feasibility of [18F]MNI-659 PET, a striatal PDE10A imaging tracer, as a imaging biomarker in PD. Background: PDE10 is highly and specifically…Altered glutamate response and calcium dynamics in iPSC derived striatal neurons from XDP-patients
Objective: Our objective was to generate an in vitro model of XDP based on striatal neurons differentiated from induced pluripotent stem cells (iPSC), followed by…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.